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Relation between biomarkers and new radiographic abnormalities in patients hospitalized with Community Acquired Pneumonia

1. To assess the incidence of pulmonary infiltrates by means of low dose CT-scan in patients with a high clinical suspicion of CAP but with a normal chest x-ray 2. The levels of biomarkers (CRP, PCT, White blood cell count) will be compared to the…

Observational multi-center, prospective study to develop a novel multi-parametric diagnostic model for hospitalized patients and patients on the Emergency Department presenting with lower respiratory tract infections and/ or sepsis.

To develop a novel multi-parametric diagnostic model for the management of patients with LRTI and/or sepsis that will be based on novel pathogen- and host-related factors.

Clinical value of ultra-low dose computed tomography compared to chest X-ray investigations in diagnosing pulmonary pathology

1. To assess the clinical value of ULDCT as compared to CXR examinations for diagnosing pulmonary pathology.2. To identify patient groups or indications that may benefit by replacing CXR by ULDCT examination. 3. To analyze the effect of…

Hyperinflation in COPD exacerbations

Objective: The main objective is to establish the strength of the relationship between improvements in dyspnea and health related Quality of Life (HR-QoL) with the decrease in hyperinflation during the resolution of a COPD exacerbation in the…

The influence of the addition of rinsing with a 0.05% chlorhexidine-containing solution to usual daily oral hygiene care on the incidence of aspiration pneumonia in physically-impaired care home residents with dysphagia.

Primary objective: To assess the influence of the addition of rinsing with a 0.05% chlorhexidine-containing solution to usual daily oral hygiene care on the incidence of pneumonia in physically-impaired care home residents with dysphagia.Secondary…

CT Iterative ReConstruction for Low-dose cardiopulmonary Evaluation: diagnosis of pulmonary infections in patients with febrile neutropenia - Circle Study

To investigate if ultra low-dose chest CT may be a better diagnostic tool than chest X-ray on day 1 of febrile neutropenia. Imaging results will be compared with a consensus diagnosis on the cause of febrile neutropenia made by an expert panel.…

A multi-center, prospective, blinded validation study to assess the accuracy of a host-response based diagnostics for distinguishing between bacterIal and viral etiology in pediatric patients with lower respiratory tract infections and fever without source

To externally validate the accuracy of a host-response based diagnostics for differentiating between bacterial and viral etiology in pediatric patients aged 2 to 60 months with LRTI or FWS.

Early detection of pulmonary exacerbations in mucociliary clearance diseases: Molecular fingerprinting by exhaled breath and microbiome analysis

Objectives: The primary objective is to establish whether expiratory VOC analysis by electronic nose and GC-MS can: Ia) discriminate between patients (CF, PCD) with and without an exacerbation and Ib) discriminate between different microbial species…

The correlation between culture of the nasopharyngeal swab, the nose swab, swab from a handkerchief and a handkerchief directly in children with an upper respiratory tract infection

The objective is determine the correlation between the outcome of the cultures of the nasopharyngeal swab, the nose swab, the swab from a handkerchief and the handkerchief.

Colonization and infection of the respiratory tract by Mycoplasma pneumoniae in children

Aims: 1. To optimize the diagnosis of M. pneumoniae infections by discriminating between colonization and symptomatic infection using quantitative PCR. 2. To study the role of host factors (age, and bacterial and viral co-infection) on infection by…

the Application of an Electronic Nose in the Early detection of Aspergillosis II

1. To establish whether serial exhaled breath analysis using eNose can detect invasive pulmonary aspergillosis in patients with prolonged chemotherapy induced neutropenia (neutrophil counts <0.5 x 10^9 for more than 7 days).2. To establish…

CRP-guided antibiotic treatment in patients hospitalized with acute exacerbation of COPD patients.
The CATCH (CRP guided Antibiotic Treatment in COPD exacerbations admitted at the Hospital) study.

OBJECTIVESIn this study CRP-guided antibiotic therapy will be compared with GOLD antibiotic therapy in AECOPD with special attention at consumption antibiotics and treatment failure.

INTRODUCTION OF VIRAL PCR DIAGNOSTICS IN PEDIATRIC RESPIRATORY TRACT INFECTION: EFFECS ON TREATMENT AND COSTS

Impact of introduction of real-time viral PCR on clinical decision making and costs in children with a respiratory tract infection.

Home spirometry to predict pulmonary exacerbations in CF: fact or fiction?

To determine if home spirometry (FEV1) predicts pulmonary exacerbation of CF before symptoms appear.

Development of a general practice-based diagnostic asthma-risk index in young children: Reaping the benefits from an ongoing cohort study.

To construct a clinical asthma-risk index for 1- to 3 year old children who visit the GP with asthma related complaints. In addition, the effectiveness of two broad treatment strategies (aggressive versus non-aggressive) in children with the same…

the Application of an Electronic Nose in the Early detection of ASpergillosis

to establish the accuracy with which the eNose can discriminate patients with invasive pulmonary aspergillosis from controls

Early detection of bacterial airway infections in children with primary ciliary dyskinesia and cystic fibrosis by electronic nose

We hypothesize that expiratory VOC-analysis by electronic nose is capable of: a.) discriminating CF-/PCD-patients with and without pulmonary infections and b.) discriminating CF-/PCD-patients and healthy controls.

An early diagnosis of asthma in young children by using non-invasive biomarkers of oxidative stress/airway inflammation

This study can be divided in two parts:1) an early asthma diagnosis in young children2) study of etiological factors in relation to the development The main objective of this study is an early diagnosis of astma by the use of non-invasive biomarkers…

Breath, sputum, serum and urine analysis for the diagnosis of tuberculosis; characterisation of volatile biomarkers for TB

The aim of our study is the development of a simple device that is able to differentiate between sputum from TB patients and non TB patients.With the knowledge and concentration of the VOCs from M. tuberculosis and possible the specific host…

An early diagnosis of asthma in young children by using non-invasive biomarkers of oxidative stress/airway inflammation, and early lung function measurements

This research proposal tests the hypothesis that an early asthma diagnosis is possible by using non-invasive biomarkers of oxidative stress/airway inflammation in exhaled air, venous blood and assessments of lung function (airway resistance by means…