Search for a trial

Colonization and infection of the respiratory tract by Mycoplasma pneumoniae in children

Aims: 1. To optimize the diagnosis of M. pneumoniae infections by discriminating between colonization and symptomatic infection using quantitative PCR. 2. To study the role of host factors (age, and bacterial and viral co-infection) on infection by…

Telemonitoring of pulmonary function in patients with Cystic Fibrosis

To assess whether internet-based telemonitoring of pulmonary function at home can prevent severe pulmonary exacerbations and lead to a reduction of hospital admission in patients with CF.

Home spirometry to predict pulmonary exacerbations in CF: fact or fiction?

To determine if home spirometry (FEV1) predicts pulmonary exacerbation of CF before symptoms appear.

Effect of Coxiella burnetii infection on health status of patients following an outbreak of Q fever.

To determine the health status of the patients of the Q fever outbreak in the Netherlands in 2007, one year after primary Q fever infection.

Routine manual hyperinflation versus on demand manual hyperinflation in intubated and mechanically ventilated post*cardiothoracic surgery patients
* A randomized controlled trial *

To compare a *routine* MH strategy with an *on demand* MH strategy in cardiothoracic surgery patients with respect to post*extubation SpO2 and FRC.

Effect of intrapulmonary administration of recombinant human activated protein C on local coagulation and inflammation after bronchial instillation of lipopolysaccharide in humans

The primary objective is to determine the effect of locally administered rhAPC on LPS-induced lung inflammation and coagulation. By using measurements on cells harvested from bronchoalveolar lavage (BAL)-fluid and in BAL-fluid supernatants, we will…

Comparison, optimization en evaluation of new and fast molecular diagnostic techniques for detection of atypical bacterial respiratory tract pathogens in clinical samples from patients with CAP.

The objective of this study is to compare, evaluate and validate some commercial molecular diagnostic techniques for atypical respiratory tract infections. Simultaneously, we intend to define the most relevant clinical material per etiological agens…

A prospective study to evaluate the safety and efficacy of AdvaCoat Mx sinus gel for treatment of chronic rhinosinusitis without nasal polyps.

The purpose of the first part of the study is the evaluation of the first 9 subjects that will be conducted to confirm the 1.5 mL AdvaCoat Mx treatment volume per side as the desired volume for the expanded portion of the study. The purpose of the…

Diagnosis of respiratory tract infections by molecular techniques in pediatric patients

Goal of this study is to obtain more insight into causative agents of respiratory tract infections in children using molecular techniques and how results of molecular test should be interpretated in relation to clinical symptoms. The optimal…

Infections in Stable Asthmatic Patients: Non Invasive Detection

The first aim of the study is to determine the prevalence of latent infections by non invasive assessment of induced sputum, exhaled breath condensate and nasal/throat swabs in stable asthmatic patients and controls. The second aim is to value…

A prospective, multinational, multicenter, randomized, double-blind, double-dummy, controlled study comparing the efficacy and safety of moxifloxacin to that of amoxicillin-clavulanic acid for the treatment of subjects with acute exacerbations of chronic bronchitis: MAESTRAL (moxifloxacin in AECB superiority trial)

The primary objective is to compare the efficacy of moxifloxacin 400 mg PO OD for five days with the respective efficacy of amoxicillin clavulanic acid 875/125 mg PO BID for seven days in the treatment of subjects with AECB. The primary efficacy…