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CRP-POCT in suspected airway infected patients in the long-term care facility

The main objective is to investigate the additional value of CRP-POCT (C-reactive protein point-of-care-test) testing in patients suspected of airway infections in long-term care facilities.

An exploratory study to assess the RSV titer in healthy volunteers as guidance for the main study

To determine pre-existing virus neutralization titer levels against RSV in a general healthy population (immunogenicity is a secondary study objective (proof-of concept) in the main phase I study).

Human Exposure to RhinOvirus * Effect of a plant-based polysaccharide food supplement on upper respiratory symptoms

This study is designed to test if consumption of a vegetable extract as a food ingredient improves resistance to an experimental respiratory tract infection with RV16 in healthy volunteers.Primary Objective: * To test and quantify the effect of the…

Community-Acquired Pneumonia: lytA TArgeted real-time quantitative polymerase chaIN reaction for improved detection of pneumococci.

Primary objective: To determine the added diagnostic value of the lytA qPCR on samples of the upper respiratory tract on top of routine microbiological tests in detecting pneumococci as responsible pathogen in patients with CAP.Secondary objective (…

RUDOLPH Study; Changes in nasal microbiota and concurrent nose soreness associated with common cold infection * a pilot using the HRV-16 challenge model in healthy subjects

Primary Objective: * Explore association between nasal microbiota composition and occurrence of nose redness and soreness during rhinovirus infectionSecondary Objectives: * Explore the potential of the HRV-16 challenge model to produce covariates of…

REspiratory Syncytial virus Consortium in EUrope (RESCEU) study: Defining the burden of disease of Respiratory Syncytial Virus in older adults in Europe.

To determine the burden of disease due to RSV in older adults.

REspiratory Syncytial virus Consortium in EUrope (RESCEU) study: Defining the burden of disease of Respiratory Syncytial Virus in Europe.

To determine the burden of disease due to RSV in young term born infants.The active cohort study is expanded to other family members during the COVID-19 pandemic to gain insight in COVID-19 related burden to families. In addition we would like to…

A Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled, Phase 3b Study to Evaluate the Safety and Efficacy of Benralizumab 30 mg sc in Patients with Severe Asthma Uncontrolled on Standard of Care Treatment

To determine the effect of benralizumab on the rate of asthma exacerbationsSubstudy: - To assess the potential for benralizumab treated patients to reduce their standard of care asthma controller regimen whilemaintaining asthma control.- To assess…

REspiratory Syncytial virus Consortium in EUrope (RESCEU): Presumed risk factors and biomarkers for RSV-related severe disease and related sequelae.

To establish biomarkers predictive of, or associated with severe infection caused by RSV in infants. This study aims to find biomarkers for disease susceptibility, disease severity and long-time sequelae following RSV infection. By extending follow-…

Diagnosing invasive fungal infections on DNA extracted from serum or plasma of immunocompromised patients with a suspected invasive pulmonary fungal infection

1. Optimise the DNA extraction process on serum and plasma to increase the sensitivity of DNA-based fungal infection diagnostic test (especially genetic mutations conferring azole resistance in invasive aspergillosis). 2. Evaluate new targeted as…

Diagnostic intervention study of low-dose CT and multiplex PCR on antibiotic treatment and outcome of community-acquired pneumonia

The aim of this study is to determine the added value of low-dose CT and PoC-PCR in the diagnostic workup of patients with CAP hospitalised to non-intensive care unit (ICU) wards in minimizing selective antibiotic pressure while maintaining patient…