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A phase 1, 4-period, crossover, open-label study in healthy volunteers to assess the effect of different types of food on a single-dose of JNJ-64417184 administered as tablets.

The purpose of this study is to investigate how quickly and to what extent JNJ-64417184 is absorbed, distributed, metabolized and eliminated from the body. The pharmacokinetics of JNJ-64417184 when it is administered in the morning following the…

The effect of polyethylene glycol treatment on gut health in Cystic Fibrosis, a pilot study

Main objective: to assess the effects of PEG treatment on bile acid homeostasis in cystic fibrosis patients. Secondary objective: to assess the effects of PEG treatment on gastrointestinal symptoms and quality of life, and on gut health-related…

A Phase 1, Open-label, Randomized, 3-way Crossover Study to Assess the Pharmacokinetic
Interaction Between JNJ-64417184 and JNJ-53718678 After Single and Multiple Dosing in
Healthy Subjects

The purpose of this study is to investigate how quickly and to what extent JNJ-64417184 and JNJ-53718678 are absorbed and eliminated from the body (this is called pharmacokinetics) when administered alone and when administered together. It will also…

Immunological Defects in Chronic Pulmonary Aspergillosis

In this study, we aim to characterize the immunological defect in patients with CPA as compared to patients with chronic obstructive pulmonary disease (COPD) without CPA on a functional, genetic, transcriptional and metabolic level.

Telemedicine in pediatric respiratory distress: a pilot study

1. Are telemedicine and FTF-evaluation similar?2. Are TM-evaluation from a general practitioners office and FTF-evaluation similar? 3. How do parents/patients value the TM evaluation?4. How do general practitioners and paediatricians value the TM…

Amoxicillin-clavulanic acid Levels in Sputum After Nebulization in AECOPD (ALSAN)

In this study we want to show adequate sputum levels are obtained throughout the day after inhalation of nebulized amoxicillin clavulanic acid in hospitalized AECOPD patients.

A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Clinical Outcomes, Antiviral Activity, Safety, Tolerability, Pharmacokinetics, and Pharmacokinetics/Pharmacodynamics of JNJ-53718678 in Adult and Adolescent Hematopoietic Stem Cell Transplant Recipients with Respiratory Syncytial Virus Infection of the Upper Respiratory Tract

To evaluate the clinical outcomes, antiviral activity, safety, tolerability, PK, and PK/PD of JNJ 53718678 in adult (ie, adult cohort) and adolescent (ie, adolescent cohort) HSCT recipients with an RSV upper respiratory tract infection (URT)I.The…