25 results
The study has the purpose and rationale to establish the antiviral efficacy of ensovibep against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, identify the optimal dose, and demonstrate its clinical value for treating COVID…
To determine the impact of prior BCG vaccination on the duration of immunogenicity of the BioNTech/Pfizer mRNA COVID*19 vaccine.
• To demonstrate the efficacy of ATR-002 versus placebo in addition to standard of care based on the clinical severity status in adult hospitalized patients with COVID-19• To show that ATR-002 in addition to standard of care shortens the time to…
Clinical Trial Protocol section 2.The main objectives of the trial are to assess the safety and tolerability of two doses of ABNCoV2, formulated with and without the adjuvant MF59, in healthy adult volunteers and to identify the dosage and…
To examine the impact of RSV infection on the diversity of the upper respiratory tract microbiome, measured by the Shannon index.
Aim 1. To study the impact of different sequences of combined influenza and SARS-CoV-2 vaccinations on immunological responses and sideeffects.Aim 2. To understand the immunological mechanisms that mediate the potential interference between…
Development of a diagnostic algorithm that will diagnose measles cases and classify (potential) contagiousness of patients following measles infection.
The overall objective of this trial is to evaluate the concept of pharmacological activity of BI 767551 in non-hospitalized patients with mild to moderate COVID-19 symptoms and to identify a potentially efficacious and safe dose regimen from Phase…
To assess the potential of AT1R and ETAR antibodies to serve as a biomarkers for clinical deterioration in COVID-19.
Primary Objective:• To create a population pharmacokinetic model of SARS-COV-2 neutralizing antibodies as present in ConvP.• To create a population pharmacokinetic model of SARS-COV-2 neutralizing antibodies as present in Nanogam*plusSecondary…
To assess the course of microcirculatory disturbances during ECMO. Furthermore, we will evaluate the effect of implementation of ROTEM in terms of thrombotic and hemorrhagic events and the use of blood products in patients on ECMO.
To determine whether it is feasible in practice to optimally monitor and treat patients with COVID-19 (Utrecht: CA-ARTI) in the home setting by using an intervention that is widely supported in the region.
To investigate the humoral and cellular immune response, and the development of immunological memory to the COVID-19 vaccination in lung transplantation patients. To clarify firstly if immunity develops in these patients and secondly, if the immune…
In this study we will investigate how safe the new compound GDC-6599 is and how well it is tolerated when it is used by healthy participants. We also investigate how quickly and to what extent GDC-6599 is absorbed, transported, and eliminated from…
Objectives: The main objective of this RE-SAMPLE cohort study is to identify from a RWD data set that will be collected, a subset of data that can be potentially used as important predictors and parameters for disease progression of COPD and CCCs,…
To study the antibody response as a disease modifying factor in the context of COVID-19, we will compare the anti-CoV antibody composition, quality and interaction with immune receptors.
To validate biomarkers that are associated with severe RSV infection and respiratory sequelae.
Study A: Validation of productive infection of RSV CHIMStudy B: Effectiveness and immunogenicity of local administration of palivizumab on prevention of experimental RSV infection
The overall aim of this study is to assess the multidimensional health status of COVID-19 survivors one year post-infection using validated subjective and objective measures.
To investigate the natural course of smell alterations in relation to COVID-19. To investigate differences in neuroanatomical structures (olfactory bulb) and neural activity between patients with anosmia and parosmia