261 results
Part 1Primary:- to evaluate the safety and nasal tolerability of single escalating i.n. GSK2245035 doses in HVSecondary:- to evaluate the systemic PK of single i.n. GSK2245035 administration in HV- to evaluate the induction of TLR7-associated PD…
1. To establish whether serial exhaled breath analysis using eNose can detect invasive pulmonary aspergillosis in patients with prolonged chemotherapy induced neutropenia (neutrophil counts <0.5 x 10^9 for more than 7 days).2. To establish…
Quantify inflammatory response (through IL-8 production) of bronchial (both commercial available cells and cultivated brushed infant cells) when exposing these to gastric juice from: hospitalized Infants, before and during PPI treatment and age…
Our primary hypothesis is that the process of nasopharyngeal and fecal colonization from birth to childhood differs in quality and quantity between infants with CF and healthy controls and that these differences are related to subsequent respiratory…
Objectives: The aim of this study is to:I Identify pathogenic mutations in novel genes, causing PCDII Develop a diagnostic PCD test, based on MPSIII Validate MPS technique for PCD.
Primary Objective: to determine the feasibility of supported MV with low tidal volumes after partial neuromuscular blockade in patients with high respiratory drive. Secondary Objective: to determine the effect of partial neuromuscular blockade on…
The Purpose of this study is to compare the surgical treatment of flail chest with the non-operative treatment regarding complications.Hypothesis: Surgical stabilization of rib fractures in flail chest results in fewer respiratory complications,…
- to determine the safety and tolerability of escalating single doses and multiple doses of ALX-0171- to evaluate the dose-limiting toxicity (DLT) level of ALX-0171 and determine the maximum tolerated dose (MTD)- to evaluate the PK of escalating…
To investigate the clinical pharmacokinetics of tobramycin and/or colistin after nasal administration. With this pharmacokinetic parameters the safety of this treatment can be investigated.
To compare the EPOS guideline with the free choice treatment of the GP for acute rhinosinusitis in general practice.
To determine the safety and tolerability of single ascending doses of oral WCK 4873 in healthy subjects. To evaluate the pharmacokinetic (PK) profile of single ascending doses of oral WCK 4873 in healthy subjects.To evaluate the effects of food on…
The purpose of this study is to evaluate whether aztreonam solution for inhalation (AZLI) is safe and effective for the treatment and complete eradication of a lung infection with PA (Pseudomonas aeruginosa) in patients with Cystic Fibrosis (CF) and…
The researchquestion of this study:Is there an association between the respiratory and cardiovascular system in early childhood? If there is an assocation, what are its determinants?
The purpose of the study is to investigate to what extent blood concentrations of Fluticasone Furoate increase proportionately to rising doses of Fluticasone Furoate in three steps administered via a powder inhalator. In addition, the absolute…
The aim of this study is to compare the time course of cytokines (markers for inflammation) in the following 3 groups: RSV-positive, ventilated patients; RSV-positive, non-ventilated patients and RSV-negative, ventilated patients. The main…
The primary objective is to determine from what age on children can operate a test inhaler correctly (handling). The secondary objectives are to determine whether children can generate a sufficiently large airflow and volume through the test inhaler…
To assess the effect of vitamin D supplementation on pulmonary function, the incidence of exacerbations and physical performance in patients with COPD.
This study is aimed to compare the changes of FRC after performance of three different placements of external stripes during recruitment maneuver
To primary objective is to demonstrate a reduction in lipoteichoic acid release in patients with pneumococcal pneumonia treated with rifampicin. This will be done by measuring lipoteichoic acid in serum and urine.Evaluable patients for Intention-to-…
OBJECTIVESIn this study CRP-guided antibiotic therapy will be compared with GOLD antibiotic therapy in AECOPD with special attention at consumption antibiotics and treatment failure.