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Venturius study
Epidemiology, genetics and immunology of viral lower respiratory tract infections in children.

Discover diagnostic biomarkers for disease severity. Increase the insight in the epidemiology of viral infections in the primary, secondary and tertiary care facilities and in the pathogenesis of and immunological response against viral infections.

Preliminary effectiveness and feasibility of two pre-operative Inspiratory Muscle Training (IMT) interventions in patients undergoing oesophageal resection

Main objective is to examine the preliminary effectiveness of preoperative IMT high-intensity in patients undergoing oesophagus resection on postoperative pulmonary complications, inspiratory muscle strength/endurance and IC stay compared to…

GRACE (Genomics to combat Resistance against Antibiotics in Community-acquired LRTI in Europe).Workpackage 10: Antibiotic Trial One

The aim is to understand which individuals benefit from antibiotics.

An open-label, single-arm study to determine the excretion balance and metabolic disposition of [14C]GW642444 administered as a single dose of an oral solution to healthy male volunteers

Primary:To compare total radioactivity (drug-related material) in plasma relative to parent plasma GW642444 concentration following a single oral dose (200µg) of [14C]-GW642444 in healthy male subjects.To determine the rate and extent of excretion…

Monitoring of influenza-like symptoms among elderly, an observational study

Primary Objective: • To determine the incidence rate of self-reported ILI.Secondary Objectives: • To determine the efficacy of 13vPnC in preventing a first episode of self-reported LRTI.• To explore the effect of 13vPnC on the incidence of self-…

A randomised controlled trial on the effectiveness of post-exposure prophylaxis (PEP) with oseltamivir in preventing influenza transmission in nursing home units

If proven (cost)effective, without inducing antivral resistance, oseltamivir could have considerable benefits in this setting, although constraints relating to implementation need to be addressed as well. If not (cost)effective if this fragile…

INTRODUCTION OF VIRAL PCR DIAGNOSTICS IN PEDIATRIC RESPIRATORY TRACT INFECTION: EFFECS ON TREATMENT AND COSTS

Impact of introduction of real-time viral PCR on clinical decision making and costs in children with a respiratory tract infection.

Telemonitoring of pulmonary function in patients with Cystic Fibrosis

To assess whether internet-based telemonitoring of pulmonary function at home can prevent severe pulmonary exacerbations and lead to a reduction of hospital admission in patients with CF.

Home spirometry to predict pulmonary exacerbations in CF: fact or fiction?

To determine if home spirometry (FEV1) predicts pulmonary exacerbation of CF before symptoms appear.

Skin Autofluorescence and Capillary Permeability: Relevance of Measuring Advanced Glycation Endproducts in Critically Ill Patients

Objective of this study is to provide evidence for the induction of AGEs in blood and tissue in patients with septic shock.

The effect of two dosing regimens cefotaxime on the presence of potential pathogenic micro-organisms in airways.

Is treatment A: cefotaxime parenteral twice daily 1 gram during four days as effective as treatment B: cefotaxime parenteral four times daily 1 gram in preventing airway colonisation by potential pathogenic microorganisms.

Development of a general practice-based diagnostic asthma-risk index in young children: Reaping the benefits from an ongoing cohort study.

To construct a clinical asthma-risk index for 1- to 3 year old children who visit the GP with asthma related complaints. In addition, the effectiveness of two broad treatment strategies (aggressive versus non-aggressive) in children with the same…

Bronchiectasis and long term Azithromycin (AZM) Treatment:
a randomised placebo-controlled trial studying disease modifying effects of immunomodulating treatment

Primary objectives1. Does prolonged antibiotic treatment with AZM reduce the number of bacterial exacerbations in patients with bronchiectasis?2. Does treatment with AZM increase lung function parameters (Δ FEV1, Δ FVC )?Secondary objectives1. Is…

Genomics to combat Resistance against Antibiotics in Community-acquired LRTI in Europe: GRACE Workpackage 9: Study on the aetiology, diagnosis and prognosis of lower respiratory tract infections in primary care

Within the observational study WP9, there will be 3 substudies. First the microbiological aetiology of LRTI will be studied by comparing test results in 3000 healthy controls to findings in 3000 adults with LRTI. Bacterial resistance rates will be…

Collection of nasal lavage fluid from experimentally infected healthy human volunteers for the generation of a GMP batch of HRV16

Experimental infections of humans with rhinoviruses, in particular rhinovirus 16 (HRV16) have proven to be a highly relevant and safe approach to study exacerbations in patients with asthma and COPD. The worldwide availability of stocks of HRV16 for…

Self-reported influenza-like symptoms among elderly

Primary Objective: • To determine the efficacy of 13vPnC in preventing a first episode of self-reported ILI.Secondary Objectives: • To determine the efficacy of 13vPnC in preventing a first episode of self-reported LRTI.• To determine the incidence…

A Randomized Open Label Study Comparing the Safety, Tolerability and Pharmacokinetics (PK) of Amantadine Hydrochloride and Ribavirin with Oseltamivir Phosphate (TCAD) Administered Orally Versus Oseltamivir alone Administered Orally to Influenza A Virus Infected Hospitalized Immunocompromised Patients

Primary: To determine the safety and tolerability of TCAD administered orally to immunocompromised patients diagnosed with influenza ASecondary: To assess the antiviral effect, the speed of symptom resolution, and the influenza complication rate of…

Effect of Coxiella burnetii infection on health status of patients following an outbreak of Q fever.

To determine the health status of the patients of the Q fever outbreak in the Netherlands in 2007, one year after primary Q fever infection.

the Application of an Electronic Nose in the Early detection of ASpergillosis

to establish the accuracy with which the eNose can discriminate patients with invasive pulmonary aspergillosis from controls

Early detection of bacterial airway infections in children with primary ciliary dyskinesia and cystic fibrosis by electronic nose

We hypothesize that expiratory VOC-analysis by electronic nose is capable of: a.) discriminating CF-/PCD-patients with and without pulmonary infections and b.) discriminating CF-/PCD-patients and healthy controls.