Search for a trial

Evaluation of the citrulline generation test (CGT) using intravenous administration of glutamine-alanine in ICU patients with multiple organ dysfunction.

Primary aimTo apply the CGT (intravenously and arterial sampling) in patient with multiple organ failure for the assessment of enterocyte function as a measure for intestinal (small bowel) barrier function.Secondary aimsTo compare the CGT with other…

An early diagnosis of asthma in young children by using non-invasive biomarkers of oxidative stress/airway inflammation

This study can be divided in two parts:1) an early asthma diagnosis in young children2) study of etiological factors in relation to the development The main objective of this study is an early diagnosis of astma by the use of non-invasive biomarkers…

Associations between genetic variation and immune response in infants with respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI)

Determine associations between genetic variation and immune response in nasopharyngeal aspirates of infants with RSV LRTI.

Breath, sputum, serum and urine analysis for the diagnosis of tuberculosis; characterisation of volatile biomarkers for TB

The aim of our study is the development of a simple device that is able to differentiate between sputum from TB patients and non TB patients.With the knowledge and concentration of the VOCs from M. tuberculosis and possible the specific host…

Routine manual hyperinflation versus on demand manual hyperinflation in intubated and mechanically ventilated post*cardiothoracic surgery patients
* A randomized controlled trial *

To compare a *routine* MH strategy with an *on demand* MH strategy in cardiothoracic surgery patients with respect to post*extubation SpO2 and FRC.

Effect of intrapulmonary administration of recombinant human activated protein C on local coagulation and inflammation after bronchial instillation of lipopolysaccharide in humans

The primary objective is to determine the effect of locally administered rhAPC on LPS-induced lung inflammation and coagulation. By using measurements on cells harvested from bronchoalveolar lavage (BAL)-fluid and in BAL-fluid supernatants, we will…

An early diagnosis of asthma in young children by using non-invasive biomarkers of oxidative stress/airway inflammation, and early lung function measurements

This research proposal tests the hypothesis that an early asthma diagnosis is possible by using non-invasive biomarkers of oxidative stress/airway inflammation in exhaled air, venous blood and assessments of lung function (airway resistance by means…

Comparison, optimization en evaluation of new and fast molecular diagnostic techniques for detection of atypical bacterial respiratory tract pathogens in clinical samples from patients with CAP.

The objective of this study is to compare, evaluate and validate some commercial molecular diagnostic techniques for atypical respiratory tract infections. Simultaneously, we intend to define the most relevant clinical material per etiological agens…

A prospective study to evaluate the safety and efficacy of AdvaCoat Mx sinus gel for treatment of chronic rhinosinusitis without nasal polyps.

The purpose of the first part of the study is the evaluation of the first 9 subjects that will be conducted to confirm the 1.5 mL AdvaCoat Mx treatment volume per side as the desired volume for the expanded portion of the study. The purpose of the…

Diagnosis of respiratory tract infections by molecular techniques in pediatric patients

Goal of this study is to obtain more insight into causative agents of respiratory tract infections in children using molecular techniques and how results of molecular test should be interpretated in relation to clinical symptoms. The optimal…

A phase III, randomized, double-blind, double-dummy, placebo-controlled, multicenter, 3-period incomplete block, multidose crossover study to determine the effect on lung function of indacaterol (150 and 300 mcg o.d.) in patients with moderate to severe COPD, using tiotropium (18 mcg o.d.) as an active control

The study is designed to compare the 24-h spirometry profile of two doses of indacaterol (150o.d. and 300 *g o.d.) with that of placebo (o.d.) and with tiotropium (18 *g o.d.) as an activecontrol in patients with COPD.

Infections in Stable Asthmatic Patients: Non Invasive Detection

The first aim of the study is to determine the prevalence of latent infections by non invasive assessment of induced sputum, exhaled breath condensate and nasal/throat swabs in stable asthmatic patients and controls. The second aim is to value…

C-reactive protein assisted prescribing for respiratory tract infections to stimulate Antibiotic stewardship; a randomised controlled trial in general practice

To determine the effect of point of care (PoC) C-reactive protein (CRP) testing and delayed prescribing on antibiotic prescribing for acute lower respiratory tract infections (LRTI) and acute rhinosinusitis in general practice.

Study on the aetiology of Community Acquired Pneumoniae in patients visiting the emergency room of a Dutch hospital

Improve the insight in the aetiology of CAP by season and by population in the Netherlands by the use of an extensive combination of microbiological techniques.Moreover this study will provide an unique sample from a well defined patient population…

Diagnosis of respiratory tract infections by molecular techniques in pediatric patients: Significance of positive samples with this ultra sensitive technique and analysis of the best sampeling method

The objective of the study is to get more insight into the interpretation of multiplex PCR test (which are so sensitive, that falls positive samples due to colonisation, or interpretation problems due to mixed infection may occur) and to expand a…

A prospective, multinational, multicenter, randomized, double-blind, double-dummy, controlled study comparing the efficacy and safety of moxifloxacin to that of amoxicillin-clavulanic acid for the treatment of subjects with acute exacerbations of chronic bronchitis: MAESTRAL (moxifloxacin in AECB superiority trial)

The primary objective is to compare the efficacy of moxifloxacin 400 mg PO OD for five days with the respective efficacy of amoxicillin clavulanic acid 875/125 mg PO BID for seven days in the treatment of subjects with AECB. The primary efficacy…

A randomized, double-blind, placebo controlled, multicentre study to determine the effect of QVA149 on lungfunction in patients with Chronic Obstructive Pulmonary Disease (COPD).

The purpose of this study is to evaluate the effects of QVA149 300/50, a fixed dose combination of QAB149 300µg and NVA237 50µg, versus placebo and two doses of QAB149 300µg and 600µg, in terms of lung function in patients with moderate to severe…

An open-label pilot study on the effects of trivalent inactivated influenza vaccination (Influvac®) in rheumatoid arthritis patients treated with rituximab

In this pilot study patients treated with a single course of rituximab or treated with multiple courses of rituximab, matched RA controls treated with methotrexate and healthy controls will be included in order to answer the following questions:1.…

The course of viral respiratory tract infections in young children

1. To investigate the etiology and incidence of respiratory tract infection in children younger than 6 years of age.2. To investigate the course of respiratory tract infections in children younger than 6 years of age.3. To investigate the clinical…

Study of viral respiratory infections in nursing homes

To determine the occurrence and variety of viral respiratory infections and their associated morbidity in the elderly and their care-takers.