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Validation of simplified quantitative methods for 3*deoxy-3*-[18F]fluorothymidine Positron Emission Tomography ([18F]FLT PET) in patients with non-small cell lung cancer treated with tyrosine kinase inhibitor (gefitinib of erlotinib).

Primary objective: association between pharmacokinetic modeling of [18F]FLT PET and simplified measures during treatment with gefitinib in patients with NSCLC to validate the use of simplified measures during treatment with gefitinib of…

MEK114375: A Rollover Study to Provide Continued Treatment with GSK1120212 to Subjects with Solid Tumors or Leukemia

To provide continued treatment with trametinib.

A randomized phase III trial of erlotinib versus docetaxel in patients with advanced squamous cell non-small cell lung cancer who failed first line platinum based doublet chemotherapy stratified by VeriStrat Good vs VeriStrat Poor (EMPHASIS, NVALT13, ETOP 3-12)

Primary: Explore the predictive ability of the VeriStrat signature, by testing for interaction between treatment arms (Arm A: erlotinib vs Arm B: docetaxel) and VeriStrat status (VSG vs VSP) using as outcome progression free survival. Secondary…

Optimising Photodynamic Therapy for the Treatment of Head and Neck Cancer

The main objective of the study is to monitor the factors effecting success of PDT, namely oxygen, photosensitizer concentration and, light dose before and during illumination to gather data that can be clinically correlated and later implemented.

Concurrent ONce-daily VErsus twice-daily
RadioTherapy: A 2-arm randomised controlled trial of
concurrent chemo-radiotherapy comparing twice-daily
and once-daily radiotherapy schedules in patients with
limited stage small cell lung cancer (SCLC) and good
performance status.

To compare the primary endpoint (overall survival) between the two arms of the studySecondary endpoints are:Local progression-free survivalMetastases-free survivalCTCAE v3.0 toxicityChemotherapy dose intensityRadiotherapy dose intensity

Smellprints in lung Cancer; the role of ENose in diagnosis and Treatment (SCENT):
part 4. Diagnostic value of the eNose in Head and Neck Cancer

The primary objective of this study is:to examine the difference in VOC pattern of exhaled air (breathprint) between patients with histology-confirmed diagnosis of head and neck squamous cell carcinoma (HNSCC) and healthy controls.The secondary…

Phase II study of sunitinib (SU011248) in patients with small cell lung cancer who are either chemo-naïve (extensive disease) or have a "sensitive" relapse

To assess the therapeutic activity of SU11248 in patients with exptensive disease small cell lung cancer who are either chemonaive or have a sensitive relapse

A Multicenter, Open Label, Randomized Study of AMG 951 in Subjects with Previously Untreated Stage IIIb/IV Non-Small Cell Lung Cancer (NSCLC) Treated with Chemotherapy with or without Bevacizumab

Objectives:Phase 1b: To determine the maximum tolerated dose (MTD) (up to 8mg/kg/day) through safety and tolerability of multiple doses of AMG 951 administered by intravenous (IV) infusion to subjects with NSCLC in combination with chemotherapy and…

Etude de phase 1 évaluant le RAD001 en association avec la radiothérapie dans les cancers bronchiques non à petites cellules

Primary objective: to evaluate the tolerability of the combination of RAD001 with radiotherapy.Secondary objective(s) To determine the antitumor activity of the combination of RAD001 (EVEROLIMUS) and radiotherapy (CR+PR+SD). To determine the…

Phase III study comparing post-operative conformal radiotherapy to no post-operative radiotherapy in patients with completely resected non-small cell lung cancer and mediastinal N2 involvement.

Main:the objective of this randomized trial would be to study disease free survival (DFS) in a population with completely resected NSCLC with homolateral lymph node mediastinal involvement histological or cytological proven. Who will randomly be…

Selective Pulmonary Artery Perfusion with carboplatin for the treatment of NSCLC: a phase I trial

To determine toxicity of selective pulmonary artery perfusion (SPAP) for the treatment of non small cell lung cancer.

Smellprints in lung Cancer; the role of ENose in diagnosis and Treatment (SCENT):
part 2. Identification of patients with lung cancer and breast cancer.

1. To determine the diagnostic accuracy of the electronic nose in the identification of lung cancer in new (referred for suspicion of lung cancer) patients based on the algorithm developed in the SCENT study part 1 (training-set).2. To determine the…

[18F]-Fluorodeoxyglucose Positron Emission Tomography in Lung Tumour Assessment, Research into Characteristics

To find correlations between tumour dimensions obtained by thresholds of uptake (SUV), metabolism (MRglu) or modelled thresholds (RTL) as measured during dynamic acquisition and anatomic (CT) and pathological data. Secondary objectives are the…

Phase I study of concurrent with involved-field thoracic radiotherapy for inoperable non-squamous cell lung cancer, followed by both concurrent and maintenance Bevacizumab

Primary objectivesTo establish the safety and tolerability of1. two doses of bevacizumab 7.5 mg/kg administered every 3 weeks with concurrent thoracic radiotherapy to 66 Gy;2. concurrent (7.5 mg/kg) and maintenance (15 mg/kg) bevacizumab during, and…

Adaptive Image-Guided Radiotherapy (IGRT) for lung cancer using repeat treatment planning CT scan and PET-CT scans.

To establish the proportion of patients in whom an initial radiotherapy plan does not provide similar, or improved coverage, on a repeat planning procedure after 15 fractions. To implement adaptive radiotherapy.

The effect of post-thoracotomy pulmonary rehabilitation on quality of life.

Primary:To evaluate the effects of a rehabilitation program on health related quality of life (SGRQ) in the 12 months postoperative period in patients with an elective thoracotomy.Secondary:To evaluate the effects of a rehabilitation program on…

Smellprints in lung Cancer; the role of ENose in diagnosis and Treatment (SCENT):
part 3. Acute effects on smellprints of chemotherapy in patients with lung cancer.

1 The primary objective is to investigate whether the eNose can discriminate the smellprints obtained before and after 1 cycle of chemotherapy in patients with specific histological types of lung cancer (NSCLC: adenocarcinoma, squamous cell…

Lobectomy for the treatment of non-small cell lung cancer (NSCLC):
video-assisted minithoracotomy (VAMT) versus muscle-sparing thoracotomy (MST)

see K1

'A one-day diagnostic track for lung cancer suspects from chest X-ray using PET-CT and subsequent multiple endoscopic investigations. (including bronchoscopy, EUS-FNA and EBUS-TBNA)'.

1. to study feasibility of a fast one-day diagnostic track including PET-CT and subsequent diagnostic/ staging investigation depending on PET-CT findings. to determine:2. the percentage of patients in which the one-day track is sufficient for…

Prospective study on cost-effectiveness of the Provox®2 and the Groningen Ultra Low Resistance tracheoesophageal shunt prostheses in voice rehabilitation of post-laryngectomy patients.

The objective of the study is a prospective study to evaluate which type of TE shunt prosthesis is the most cost-effective.