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Complete endosonographic intrathoracic nodal staging of lung cancer patients in whom SABR is considered.

Complete endosonographic (combined endobronchial and esophageal) staging of hilar and mediastinal lymph nodes in patients with (suspected) non-small cell lung cancer (NSCLC) will result in change of loco-regional nodal status in 20% of patients, in…

A phase II trial evaluating the safety and efficacy of the addition of concurrent anti-PD-1 nivolumab to standard first-line chemotherapy and radiotherapy in locally advanced stage IIIA/B Non-Small Cell Lung Carcinoma

Primary objective: To assess the feasibility of the addition of nivolumab consolidation to standard first-line chemotherapy and radiotherapy in locally advanced stage IIIA/B NSCLC, as defined by the rate of grade *3 pneumonitis (CTCAE V4.0) 6 months…

A prospective double-blind randomized Phase III study of 300 mg vs. 150 mg erlotinib in current smokers with locally advanced or metastatic NSCLC in second-line setting after failure on chemotherapy

To compare the efficacy of two dose levels of erlotinib (150 mg and 300 mg) on progression-free survival (PFS) in current smokers with stage IIIB/IV NSCLC after failure of first-line platinum-based chemotherapy.

Validation of simplified quantitative methods for 3*deoxy-3*-[18F]fluorothymidine Positron Emission Tomography ([18F]FLT PET) in patients with non-small cell lung cancer treated with tyrosine kinase inhibitor (gefitinib of erlotinib).

Primary objective: association between pharmacokinetic modeling of [18F]FLT PET and simplified measures during treatment with gefitinib in patients with NSCLC to validate the use of simplified measures during treatment with gefitinib of…

Illness Perceptions in patients with lung cancer

The aim of this research is to gain a more detailed insight into the illness perceptions of patients with lung cancer. With this insight it is our aim to improve biopsychosocial care for these patients. Research question: What are the illness…

A phase Ib open label clinical trial of continuous once daily oral treatment usin BIBW 2992 plus cetuximab (Erbitux) in patients with non-small cell lung cancer (NSCLC) with progression following prior erlotinib (Tarceva) or gefitinib (Iressa)

The primary aim of this study is to determine the Maximum Tolerated Dose (MTD) of BIBW2992 treatment in combination with cetuximab in patients with Non-Small Cell Lung Cancer with acquired resistance to erlotinib or gefitinib.Safety,…

Evaluation of radiation induced pulmonary hypertension using MRI in stage III NSCLC patients treated with chemoradiotherapy. A Pilot Study.

The objective is to test the hypothesis that radiotherapy for lung cancer induces an increase in pulmonary artery pressure.

A randomized phase II study of paclitaxel-carboplatin-bevacizumab with or without nitroglycerin patches in patients with stage IV non-squamous-non-small cell lung cancer: NVALT12

The addition of NTG patches to bevacizumab containing chemotherapy (experimental arm) improves PFS in patients with stage IV non-squamous NSCLC, compared to bevacizumab containing chemotherapy without NTG (control arm)Secondary Objectives: Objective…

Diagnostic Accuracy of an Electronic Nose as Compared to Combined Conventional CT-Scanning, Autofluorescense Scopy for the Detection of Early Endobronchial Squamous Cell Cancer after prior History of Head-and-neck Cancer or Lung Cancer

To evaluate the value of volatile organic compounds analysis by eNose in the early detection of second primaries or metastasis (and early lesions).

High Definition bronchoscopy, an exploratory study of diagnostic value in comparison to standard white light bronchoscopy and autofluorescence bronchoscopy

(1) Investigate diagnostic performance (sensitivity) of HD bronchoscopy, with or without surface enhancement or tone enhancement in comparison to standard WLB for detecting abnormalities of the tracheobronchial tree. Furthermore we aim to…

eNose Analysis of Air Sampled by Bronchoscopy.

We hypothesize that a diagnostic algorithm based on tumor site-specific VOCs enables the discrimination of lung cancer patients and controls compared to exhaled breath sampling.We aim to test this hypothesis by conducting a cross-sectional…

Stereotactic Radiotherapy for Metastasis to the Lung

To determine whether SRT achieves a local control rate comparable to surgery in patients with metastatic lung disease.

Detection and treatment of endobronchial (pre-)malignant lesions after treatment of early stage lung cancer in COPD patients

PRIMARY OBJECTIVE1. To assess the effect of screening with AFB and subsequent treatment of endobronchial lesions in addition to screening with CT scan on cancer free survival of COPD patients previously treated for early stage NSCLC. SECONDARY…

Arm function and quality of life after trimodal treatment of sulcus superior tumour (SST)

Determine arm and shoulder function and quality of life scores before and after treatment of SST. The untreated extremity can serve as a control.Determine riskfactors for a poor functionale outcome and quality of life after treatment for SST (e.g.…

Smellprints in lung Cancer; the role of ENose in diagnosis and Treatment (SCENT):
part 4. Diagnostic value of the eNose in Head and Neck Cancer

The primary objective of this study is:to examine the difference in VOC pattern of exhaled air (breathprint) between patients with histology-confirmed diagnosis of head and neck squamous cell carcinoma (HNSCC) and healthy controls.The secondary…

Smellprints in lung Cancer; the role of ENose in diagnosis and Treatment (SCENT):
part 1. Differences in smellprints between patients with lung cancer and breast cancer

Primairy objective: we will examine the difference in VOC pattern of exhaled air between patients with histology-confirmed diagnoses of non small cell lung cancer vs breast cancer. Secundairy objective: a. to confirm the potential of the electronic…

Treatment of larger tumor volumes or >= 2 lung tumors simultaneously in lung cancer patients using SBRT in a mean-lung dose escalation study

Primary objective: the assessment of the maximal mean lung dose that is accepted to safely treat large peripheral tumors or 2 lung metastases simultaneously using SBRT. Secondary objectives:- evaluation of local control - evaluation of regional…

Chloroquine as an anti-autophagic radiosensitizing drug in stage I-III small cell lung cancer (SCLC) patients: A phase I trial.

To determine the toxicity of adding chloroquine in escalating doses in patients with small cell lung cancer to standard therapy.

Discrimination of benign and malignant human tissue during percutaneous interventions using optical spectroscopy techniques

In our previous studies using optical spectroscopy, both ex vivo and in vivo, most promising results were obtained for tissue diagnosis. Moreover, invasive procedures for biopsy or radiofrequency ablation in these tissues are all very common. Thus,…

REQUITE: Validating predictive models and biomarkers of radiotherapy toxicity to reduce side-effects and improve quality-of-life in cancer survivors

Primary ObjectiveTo establish a prospective cohort of patients undergoing radiotherapy for breast, prostate or lung cancers following local regimens and collecting standardised radiotherapy toxicity data, non genetic risk factor data and samples for…