31 results
Primary objective: To investigate the effect of supplementation of a single intramuscular dose of 80 mg triamcinolone on the level of MPT-induced dynamic hyperinflation, in adult asthma patients with demonstrated dynamic hyperinflation. (Part 1)…
This study aims to investigate the process and outcome of the implementation of a coaching intervention in COPD care in the Friesland province.
zie nederlandse samenvatting
We postulate that exhaled molecular profiling obtained from *breathprints* by electronic nose:1. Will discriminate eosinophilic asthma from non-eosinophilic asthma2. Is associated with individual biomarkers and specific proteomic profiles in induced…
Our hypothesis is that antibodies of COPD patients contribute to inflammatory processes leading to cell death, and that the level of cytotoxicity differs between COPD patients and healthy volunteers. The prime aim is to detect differences in…
The aim of the current proposal is to investigate the effects of changes in lifestyle, food intake, physical activity and health related behavior during adolescence on development of asthma, allergy and other chronic diseases. Health outcomes that…
Primary Objective: 1) To investigate if the intestinal permeability acutely increases during physical activity (submaximal cycle ergometry or ADL test) in clinically stable patients with moderate to severe COPD; 2) To investigate if the intestinal…
The aim of the extended follow-up of the PIAMA cohort is: To investigate changes during the ages of 8 to 11-12 years in lifestyle, nutrition, physical activity and health related attitude and behavior that are relevant to the development of asthma,…
To investigate whether cough measurements by means of VAS (0-100 points) after 6 months (+/- 6 points) in patients with chronic cough who are diagnosed and treated by a nurse practitioner outpatient clinic are equal to an outpatient clinic leaded by…
The aim of this study is to access the effect of low and high VT (ml/kg) on pulmonary and systemic inflammatory responses and the release of oxygen and nitrogen free radicals in the paediatric patient with and without ALI.
which particles can be found in induced sputum of construction workers? What is the composition, size and concentration of quartz particles measured in sputum of the different exposure groups?
Primary objective is to show the presence of endogenous ligands of TLR4 in the lung of patients being mechanically ventilated in a standardised way with clinical parameters. Secondary objective is to investigate the amount of endogenous ligands of…
Research questions:Is the chronic inflammatory response in COPD caused by a dysfunction of regulatory T cells?1. Is the number of Tregs decreased in COPD?2. Is the function of the Tregs impaired in COPD? And if so,a. Is this associated with a…
With this study we aim to provide insight in the role of pulmonary RAS in the pathogenesis of ARDS in neonates and children. This study is performed in the context of a comparative study assessing the impact of age on the pulmonary RAS in ARDS. We…
To evaluate an intervention to improve medication intake behaviour in adolescents with asthma.
Our primary objective is to identify which intrinsic defect in Tregs is crucial for sarcoidosis pathology. To this end we will examine the genetic and functional properties of Tregs in the peripheral blood and at the site of disease, i.e. the lung…
To better understand the progression of early CF lung disease we aim to study lipid profiles and PMN dysfunction in relation to the severity of early lung disease in infants with CF, using BALF samples and peripheral blood. To optimally study these…
The aims of the current study are to compare available tests for small airway function in asthmatic patients and to assess differences in small airway function between obese and non-obese asthmatic patients.
The main objective of our Center for Translational Pediatric Pulmonology (CTPP) is to establish models of bronchial epithelial function in children, by (1) epithelial organoid cultures derived from bronchial epithelial cells; (2) bronchial brushings…
Primary Objective: To identify the variability in the circulation of the number of patrolling monocytes and their expression of CX3CR1 obtained from adult ZZ-AATD patients compared to spouse controls.Secondary Objective(s): (1) To identify if low…