74 results
The primary objective of this study is to evaluate whether use of the TrachFlush reduces the need for tracheal suctioning. In a selection of patients, one secondary objective is to ascertain the exact volume of airway secretions that is pushed past…
Primary Objective: a reduction in bronchoconstriction, measured by auto-PEEP, in patients with AE-COPD. Secondary Objective(s): * To test for a dose-dependency. * Decrease in pulmonary artery pressures* Enhance cardiac output* Measure occurrence of…
Our objective is to evaluatie the effect of an online, psychologist-guided intervention (eMBCT) on fatigue, stress and overall QoL in patients with sarcoidosis. Not only patient-reported outcomes, but also objective markers such as hair cortisol…
Our objective with this proposal is to study the interaction between nintedanib and green tea capsules with > 60% ECGC in fibrotic ILD patients. Depending on the presence and magnitude of the interaction, we will be able to give practical…
to investigate the safety and tolerability of pirfenidone in asbestosis patients
Primary ObjectivesThe primary objectives for this study are as follows:* To evaluate the safety and tolerability of atezolizumab and ipilimumab when administered in combination in patients with advanced or metastatic non-small cell lung cancer (…
The aim of this study is to evaluate the effect of a swallowing treatment program on the frequency of COPD exacerbations in the COPD gold II-IV patient groups. The secondary objective is to evaluate the possible improvement in swallowing function.
In this study we will investigate whether a home monitoring program improves disease-specific HRQOL for IPF patients through appropriate medication use and subsequently results in better objective and subjective outcomes.
The objective of the trial is to assess the efficacy and safety of nintedanib in the treatment ofSSc with ILD at a dose of 150 mg bid compared to placebo.
To evaluate whether discontinuation of VKAs results in a higher vitamin K status and deceleration of the rate of mature cross-linked elastin degradation.
Primary ObjectiveTo evaluate the efficacy of lumacaftor/ivacaftor combination therapy (LUM/IVA) in subjects with cystic fibrosis (CF) 12 years of age and older who have at least one A455E mutation.Other Objectives* To explore the association between…
Primary:Evaluate the long-term safety and tolerability of dupilumab in patients with asthma who participated in a previous dupilumab asthma study.Secondary:Evaluate the efficacy of dupilumab in patients with asthma who participated in a previous…
To compare ventilation with PEEP titrated to the lowest possible PEEP level (restricted) with ventilation the currently practiced PEEP level (liberal) in intensive care patients without ARDS.
In this study we aim to determine the feasibility of a home monitoring program, consisting of an online tool (IPF-online), home spirometry and online collecting of PROs in patients with IPF.