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Initiation of HOme MEchanical ventilation at home in a selective group of patients with chronic hypercapnic Respiratory failUre in the Netherlands

Patients with chronic respiratory failure currently start their ventilatory support in hospital as stated in national guideline. However, as these patients are severely disabled, a stay at the hospital for several days is experienced by many as very…

Initiation of chronic ventilatory support outside the hospital.

We want to investigate if it is possible to set up the entire process of home mechanical ventilation outside the hospital. This means practically that the patients will not be admitted to the hospital. The goal of this study is to answer the…

Vacuum-Assisted Closure versus Closed Drainage using Redon Catheters for the Treatment of Mediastinitis: a Prospective Study

.Currently, vacuum-assisted drainage and closed drainage using redon catheters are widely accepted methods for the treatment of mediastinitis. However, it is unknown which technique is considered to be the most effective. We hypothesize that closed…

Clinical Outcome of Postoperative Mediastinitis: Sternal Closure Versus Conventional Treatment

The aim of this study is to compare the clinical outcome and survival in patients undergoing sternal closure treatment or conventional treatment for postoperative mediastinitis. The secondary objective is to determine incidence of mediastinitis and…

Repeat CT for evaluation of inter- and intrafraction changes during curative thoracic radiotherapy; An exploratory pilot study.

To evaluate the impact of inter-fraction tumour and organ geometrical dislocation for moving tumours on photon and proton radiotherapy treatment plans in order to create robust intensity modulated photon- and/or proton treatment plans.

Early Fixation versus Conservative therapy of multiple, simple rib fractures (FixCon); a multicenter randomized controlled trial

Primary Objective:To examine the effect of ORIF versus nonoperative treatment of multiple simple fractured ribs on the rate of pneumonia within 30 days after trauma, in adult patients who sustained multiple simple fractured ribs.Secondary Objectives…

Optimal postoperative chest tube and pain management in patients surgically treated for primary spontaneous pneumothorax; a randomized controlled trial.

Our objective is to compare the efficacy of early chest tube removal combined with single-shot PVB versus standard treatment (chest tube for at least 3 days and thoracic epidural analgesia (TEA)) after surgery for PSP. Efficacy is defined as proving…

Randomized Controlled Trial of Laparoscopic Primary Diaphragm Repair with Sutures Alone versus Sutures Reinforced with Mesh for Hiatus Hernia: A Long-Term Follow-Up

To assess the recurrence of hiatal hernia five to ten years after repair using sutures versus sutures reinforced with non-absorbable mesh.

Intercostal nerve cryoablation versus thoracic epidural analgesia for minimal invasive Nuss repair of pectus excavatum: A protocol for a randomized clinical trial (ICE trial)

Primary objective of the current study is to determine the impact of intercostal nerve cryoablation on postoperative length of hospital stay compared to standard pain management of pectus excavatum patients treated with the minimal invasive Nuss…

Expiratory muscle activity and function in critically ill ventilated patients

The primary objective is to investigate the coordination (functional and timing) between the different respiratory muscles in ICU patients under mechanical ventilation during assisted breathing and during a spontaneous breathing trial. To this end,…

Breath hold techniques for radiotherapy of esophageal carcinoma; a feasibility study.

Part 1: The main objective of the first part of the study is to determine the most optimal method for DIBH (active breathing control vs voluntary coached) and its reproducibility. Based on these findings, one of these methods will be selected for…

The effect of Virtual Reality on pulmonary recovery and mobility in patients with blunt chest trauma.

Primary Objective:To investigate the effect of respiratory and physical exercises in VR on pulmonary recovery compared to the standard of care of patients suffering from blunt chest trauma.Secondary Objective(s):- To investigate if VRx can improve…

Effects of high-frequency neuromuscular electrostimulation with external weights in patients with chronic obstructive pulmonary disease with severe symptoms of shortness of breath and dysfunction of lower extremity muscles: a pilot effects study.

The aim of this study is to determine whether external weights affect the intensity of NMES and the possible effects on metabolic processes and muscle activity in COPD patients.