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Treatment of apomorphine-induced skin reactions: a pilot study

The primary objective of this pilot study is to determine the effectiveness of four treatment options for local skin reactions induced by continuous subcutaneous apomorphine infusion, as compared to no treatment.The primary endpoint is the measured…

pharmacokinetic-pharmacodynamic modeling of S(+)-ketamine in fibromyalgia

To test the hypothesis that ketamine has a modulatory effect on fibromyalgia

Safety and efficacy of interleukin-1 inhibitor anakinra for the amelioration of fever during neutropenia and mucositis in patients with multiple myeloma receiving an autologous hematopoietic stem cell transplantation after high-dose melphalan

The primary objective is to evaluate the safety and efficacy of anakinra in patients with multiple myeloma receiving high-dose melphalan (HDM) in the preparation for an autologous hematopoietic stem cell transplantation (SCT). Secondary objectives…

The effect of explantation of silicone breast implants on neuroimages of the brain in ASIA-syndrome patients: a pilot fMRI-study

To investigate the effect of explantation of silicone breast implants on neuroimaging of the brain (fMRI) in ASIA syndrome patients to gain more insight in the neurophysiological basis and nociceptive system of ASIA syndrome due to SIIS and the…