572 results
The primary objective in this observational study is to determine microcirculatory profile in preterm and term neonates. We would like to determine how the microcirculation changes in time during the phase of adaptation and correlate inter- and…
1. Determining whether or not the vitamin K tablets have the same biological availability in humans as the vitamin K solution has.2. Determining whether or not the vitamin K tablets are as effective as the vitamin K solution is.
Objective of the study:Investigating with use of the classical coagulation tests on one hand and with the ROTEM on the other hand what is exactly becoming disturbed in the coagulaton because of bleeding during surgery of the aorta abdominalis,…
Is there an increase in markers of trombogenese (platelet activation, d-dimeer, von willebrandfactor, OPG) in elderly users of antipsychotics six to ten days after the start in comparison to the same markers before start of the antipsychotic…
The aim of this study is to investigate if there is a correlation between the clinical phenotype (defined as age of first bleeding) of patients with haemophilia A and the results of the whole clotting assessment (TMETP + T-TAS).The results will…
To characterise the different platelet activating pathways using the FACS assay and the different steps of primary hemostasis with a perfusion flow model in patients with hereditary thrombocytopathies; Storage Pool Disease (SPD), Glanzmann*s…
To investigate the functionality of the hemostatic system in patients at one year after OLT. Specifically, we will investigate the function of primary hemostasis (i.e., blood platelets), secondary hemostasis (i.e, the mechanisms responsible for…
The gaol of the present study is to determine the role of platelet derived TFPI on coagulation in healthy male subjects (n=10) and in healthy female subjects either using ( n=10) or not using oral contraceptives (n=10). Additionally 8 healthy…
Primary:To determine the safety, tolerability, and pharmacokinetic (PK) profile of single ascending intravenous (iv) doses and of multiple ascending iv doses of FMX-8 in healthy subjectsSecondary:To evaluate the pharmacodynamics (PD) of FMX-8 in…
Objective:The hypothesis of this study is that laboratory markers for blood coagulation, platelet activity and inflammation may help to identify patients at risk for a recurrent cardiovascular event after ACS. Secondary, we expect to find…
To assess the costs and effects of tailoring the duration of elastic compression stocking (ECS) therapy after deep vein thrombosis (DVT) to individual patients needs.
Evaluation of the safety and efficacy of bortezomib combined with cyclophosphamide and dexamethasone for induction and maintenance therapy.
To evaluate the inter- and intra-subject variability in pharmacokinetics (PK) and pharmacodynamics (PD) of study drug following a two-period repeated single dose of 2 mg delivered by subcutaneous (SC) injection in healthy volunteers.
To investigate the in vitro effect of pro- and anticoagulants on the hemostatic capacity of plasma from patients with liver cirrhosis.
Our principal aim is to assess the effects of phlebotomy on aortic augmentation (AIx) and central BP in supine position and after standing; second, to assess the effects of counter maneuvers (leg crossing and thigh compression) on aortic…
Primary Objective: The primary objective is to investigate the effect of hypoxia on blood coagulation using different techniques, among others the very sensitive TG assay in whole blood and plasma.Secondary Objective: The secondary objective is to…
Primary objective: to quantitatively characterize the pharmacokinetics and associated inter-individual and inter-occasion variability of prophylactic nadroparin in critically ill patients.Secondary objectives: To screen and possibly quantify the…
To study the effect of different treatment modalities, in newly diagnosed ITP patients, on disease activity, platelet activity, the results of the MAIPA, and the relation between these.
Primary :To evaluate the prothrombin time (PT) in healthy volunteers treated with edoxaban alone or preceded by apixaban.Secondary : To assess the effect of edoxaban alone or preceded by apixaban on additional pharmacodynamic (PD) assays: activated…
To assess the Pharmacokinetic and Pharmacodynamic properties of three dosages of Coagulation Factor VIIa (Recombinant) in congenital hemophilia A or B patientsTo assess the safety of three dosages of Coagulation factor VIIa (Recombinant) in…