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Reducing the incidence of daily life pain in patients with sickle cell disease

In this study the effect of the administration of NAC on the frequency and severity of pain and painful crises in daily life will be assessed as well as the related frequency and length of hospital admissions and health related quality of life. In…

Low dose iron chelation as TReatment of Oxidative stress in Sickle cell disease; TROS study

To study the safety and efficacy of deferasirox as treatment of oxidative stress in adult subjects with sickle cell disease.

A Phase II, multicenter, randomized, open label two arm study comparing the effect of crizanlizumab + standard of care to standard of care alone on renal function in sickle cell disease patients * 16 years with chronic kidney disease due to sickle cell nephropathy

To evaluate the effect of crizanlizumab + standard of care compared to standard of care alone on albuminuria (ACR) decrease at 12 months