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Low dose iron chelation as TReatment of Oxidative stress in Sickle cell disease; TROS study

To study the safety and efficacy of deferasirox as treatment of oxidative stress in adult subjects with sickle cell disease.

A Phase II, multicenter, randomized, open label two arm study comparing the effect of crizanlizumab + standard of care to standard of care alone on renal function in sickle cell disease patients * 16 years with chronic kidney disease due to sickle cell nephropathy

To evaluate the effect of crizanlizumab + standard of care compared to standard of care alone on albuminuria (ACR) decrease at 12 months