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Patients with DVT on unusual places and/or < 45 years of age

Frequency of PNH in a selection of patients with DVT. In several publications PNH has been described especially in patients with DVT and younger than 30 years of age and/or with DVT on unusual places.

Leiden's IVIg trial in Rhesus disease of the Neonate

AimTo determine whether the prophylactic use of IVIg reduces the need for ET in neonates with Rh-D hemolytic disease.

Randomized controlled trial on the use of EPO to reduce top-up transfusions in neonates with red blood cell alloimmunization treated with intrauterine transfusions.

The primary objective of this study is to investigate whether darbepoetin alfa is effective in reducing the incidence of late anemia in infants with HDN treated with IUT and therefore in decreasing the number of top-up transfusion required per…

The effect of GBT440 on cerebral perfusion and oxygenation (GBT440-MRI side study)

1. To assess the effect of increased hematocrit on cerebral perfusion as depicted by CBF and CVR.2. To determine the effect of GBT440 on oxygen saturation of the cerebral vasculature and the oxygen local consumption.3. Determine the dose response…

Cerebrovascular Reserve measUrements In Sickle cell diseasE, a MRI-based study

The current study aims to evaluate magnetic resonance imaging (MRI)-based CVR measurements with ACZ in SCD. It*s primary objective is to assess whether there is a correlation between CVR with silent cerebral infarcts (SCI) (i.e. the cerebrovascular…