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Inguinal or Ilio-inguinal Lymphadenectomy for Patients With Metastatic Melanoma to Groin Lymph Nodes and no Evidence of Pelvic Disease on PET/CT Scan - A Randomised Phase III Trial (EAGLE FM)

This study aims to provide a more rational evidence base for appropriate management for metastatic melanoma in the groin LNs, through assessing the effect of the addition of ipsilateral pelvic lymphadenectomy on patient disease-free survival (DFS),…

Lymphomics; improving the understanding of the anatomy of the lymphatic system and the direction and velocity of lymph flow

To improve the knowledge and understanding of the (patho)physiology of lymph disorders Main objective: the anatomy of the central lymph vessels, the velocity and direction of lymph flow and its influencers and thoracic duct outlet location and…

Improving the understanding of the anatomy and lymph flow in the central lymphatic system in patients with Noonan Syndrome Spectrum Disorder

To get a better insight into the central conducting lymphatic system in adult volunteers with Noonan Syndrome (NS) without clinical symptoms or signs of lymphatic disease compared to NS and CardioFacioCutaan syndrome patients with severe lymphatic…

Validation of a Magnetic Resonance Lymphography protocol in upper extremity lymphedema and healthy subjects*

To determine the feasibility and applicability of the MRL protocol by comparing the images in upper extremity in patients with secondary lymphedema and healthy subjects, and to assess differences in the lymphatic system between the lymphedema…

Medical assessment of adverse health outcomes in Dutch childhood cancer survivors; a nationwide project; SKION LATER Q2008 onderzoek:
Impaired splenic function in long-term survivors of childhood cancer; diagnostic and therapeutic strategies.

Primary aims:1. To assess the efficacy of pneumococcal vaccination in patients with impaired splenic function after cancer therapy. 2. To compare the number of IgM memory B-cells of survivors after splenectomy with survivors who received TBI, and…