Search for a trial

Measuring TMPRSS6 expression to clarify genetic diagnosis in IRIDA

(Primary) Determine whether measuring the expression level is a good functional test for confirming the genetic diagnosis in IRIDA by establishing the relation between the TMPRSS6 mRNA expression and the phenotype in IRIDA patients and their family…

Iron and malaria: the central role of hepcidin and macrophage function

In the current proposal, we propose an in vitro study to explore the interaction of malaria infection, the parasitized erythrocyte, and monocyte iron metabolism. We aim to study the role of hepcidin and to explore a) the pathways involved in malaria…

Bone marrow evaluation in patients with suspected aplastic anemia

In our laboratory we are able to characterize and culture MSCs. In order to study more extensively the possible alterations in MSC biology in AA we will investigate bone marrow cells of patients with newly diagnosed AA and at the time of response…

Single-cell analysis of somatic mutations to understand and improve blood formation after hematopoietic stem cell transplantation

We aim to quantify the contribution of individual HSCs to blood (re-)generation in pediatric HSCT recipients and their donors, and to unravel the consequences of transplantation on HSC long-term genomic integrity.

Long-term integrity of hematopoiesis in pediatric stem cell transplantation survivors

We aim to determine the long-term integrity of hematopoiesis in pediatric and young adult HSCT survivors.

The Effects of Transfusion of Red blood cells In the critically ill II

To determine the effect of transfusion on the expression of PS in critically ill patients with and without inflammation.