15 results
The study will compare the change in cutaneous cellular oxygen availability, measured as mitochondrial PO2 (mitoPO2) between a fluid challenge and a blood transfusion in chronic anemia patients.
(Primary) Determine whether measuring the expression level is a good functional test for confirming the genetic diagnosis in IRIDA by establishing the relation between the TMPRSS6 mRNA expression and the phenotype in IRIDA patients and their family…
The objective of this study is to evaluate the additional value of novel anemia markers (RET-HE, RPI, sTfR, sTfR/log(ferritin), transferrin/log(ferritin)) in a prospective, randomized study design. Our hypothesis is that the novel anemia markers can…
to analyse the applicability of neutron activation analysis in measuring the absorption of a trace dose of the stable 58 Fe isotope orally given as ironsulphate
We aim to determine whether the change in Ret- He, RBC- He and hepcidin concentration to one or two weeks iron supplementation therapy predicts the increase in hemoglobin concentration after 6 weeks of oral iron supplementation therapy in anemic…
Serum hepcidin levels are elevated in hemodialysis patients and may contribute to functional iron impairment and thus to ESA-resistance. Kinetics of hepcidin in hemodialysis patients has not been studied in detail. This study is designed to provide…
In the current proposal, we propose an in vitro study to explore the interaction of malaria infection, the parasitized erythrocyte, and monocyte iron metabolism. We aim to study the role of hepcidin and to explore a) the pathways involved in malaria…
In our laboratory we are able to characterize and culture MSCs. In order to study more extensively the possible alterations in MSC biology in AA we will investigate bone marrow cells of patients with newly diagnosed AA and at the time of response…
The first objective is to explore whether epo regulation and expression, at the age of two weeks after birth and three to six months post-term, are associated with the course of Hb levels. Furthermore, we will assess if epo regulation and expression…
To measure a change in Hemoglobin levels upon a change in posture from supine to upright in in ICU patients.
We aim to quantify the contribution of individual HSCs to blood (re-)generation in pediatric HSCT recipients and their donors, and to unravel the consequences of transplantation on HSC long-term genomic integrity.
We aim to determine the long-term integrity of hematopoiesis in pediatric and young adult HSCT survivors.
The objective of this study is to validate the tHb determined by sOCT by comparing it to the tHb from invasive blood sampling. From this comparison, we aim to optimize our data analysis procedure for in vivo sOCT measurements. We also aim to…
To determine the effect of transfusion on the expression of PS in critically ill patients with and without inflammation.
To assess the relation between bleeding tendency (patients with WHO grade II or more) and platelet function and platelet /count in patients with hemato-oncological disease