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An Open Label Extension Study of Voxelotor (GBT440) Administered Orally to Participants with Sickle Cell Disease Who Have Participated in Voxelotor Clinical Trials

The objective of this open-label extension (OLE) study is to assess the effect of long-term safety and treatment effect of Voxelotor in participants who have completed treatment in Study GBT440-031, using the following parameters:- Safety based upon…

Cross-sectional study for evaluation of Platelet function and Immune profile in patients with Chronic ITP

To assess platelet function and coagulation parameters in adult chronic ITP patients in relation to their bleeding phenotype

Exploring the clinical utility of a novel multichannel platelet function test in patients with stable coronary disease

The main objective of the current study is to investigate platelet reactivity and underlying mechanisms using the novel multi-microspot analysis in a group of patients with SIHD and a healthy control group.

A 4-part Phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of M254 in healthy volunteers and in patients with immune thrombocytopenic purpura.

The purpose of this study is to investigate how safe the new compound M254 is and how well it is tolerated when it is administered to healthy volunteers and patients with immune thrombocytopenia (ITP). M254 has not been administered to humans before…