51 results
The primary objective is to compare the haemostatic effect of VHA-guided transfusion strategy versus optimized CCT guided transfusion strategy in haemorrhaging trauma patients. The secondary objectives of the study are to determine the effects of…
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…
To understand why statins are able to decrease the risk of developing venous thrombosis, by analyzing whether statins can influence pathways that inhibit coagulation.
Main: To confirm the findings of our previous, explorative study that the overall FXI plasma levels in patients with menorrhagia are lower than in controls. Secondary: To establish the prevalence of FXI mutations/polymorfisms in patients with…
Primary Objectives:- Evaluate changes in the immune system upon exposure to FVIII in patients with severe hemophilia A - Identify immunologic predictors of FVIII inhibitor development or tolerance
The overall aim of this study is to evaluate the use of the thrombin generation test in patients with CKD, including haemodialysis-dependent patients.
To define the role of genetic variations in SNARE protein genes in the regulation of VWF plasma concentrations and their effect on other substances secreted by WPBs and alpha-granules and coagulation parameters under physiological circumstances.
The objective of this study is to investigate if the Thrombin Generation Curve has an additional, possible more accurate, value besides the conventional tests such as PT, APTT, INR, AT and the mearument of coagulationfactors for determining…
The aim of the study is to understand the effects of CPB on coagulation and fibrinolysis to improve treatment of excessive blood loss (>2L/24 hours or >200 mL/hour) after cardiac surgery.The objective of this study is to differentiate…
to investigate the presence and frequency of FXI gene mutations in patients with menorrhagia and healthy volunteers.
Objevtive of the study is to analyze a European cohort of patients with INCIPH based on scientific analyses of clinical, laboratory and morphological data prospectively collected. HIV patients with known splenomagaly will be invited for abdominal…
The primary objective of this study is to establish a panel of markers that can be used for further research into the understanding of the pathogenesis of PTS.
The aim of this study is to investigate whether exercise changes FVIII levels in patients with moderate and mild haemophilia.
- Evaluation of mean increase in serum creatinine and the incidence of CIN following CT-PA without prehydration compaired to a short prehydration regime with sodium bicarbonate during one hour.- Furthermore, the risk of developing CIN after CT-PA…
• Evaluation of the incidence of CIN after CT-angiography with a hydration regime during 1 hour with sodium bicarbonate compaired to a hydration regime with saline during 24 hours.• Furthermore the risk for developing CIN after CT-angiography is…
We will study the effects of the proteins of the contact activation system in thrombus formation, embolization and degradation in several coagulation assays.
We aim to evaluate the use of MRDTI in the diagnosis of acute proximal DVT, comparing the findings with CUS. To evaluate the outcome of patients with positive and negative MRDTI and CUS, clinical outcome after 3 months of follow-up will be measured…
In this study, we will assess whether healthy men with high-normal serum CK display attenuated platelet aggregation, compared to those with low-normal serum CK.
The aim of this study is to characterize the early immune response against F VIII concentrates in patients with severe hemophilia A before and during inhibitor development.
Inflammatory and endothelial parametersTo investigate the influence of factor VIII concentrate infusion on inflammatory and endothelial parameters in patients with severe hemophilia A.Platelet activity and responsivenessTo investigate the influence…