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Aspirin for the prevention of spontaneous preterm birth

The objective was to assess the effectiveness of low-dose aspirin in the prevention of recurrent preterm birth.

T-Cell Mediated Plaque Inflammation and Atherosclerosis in Stage III Melanoma Patients on (neo-)adjuvant Immune Checkpoint Inhibitors: a prospective matched cohort study

To investigate the effects of ICIs (anti-CTLA4, anti-PD1, combination anti-CTLA4/PD1) on vascular inflammation (PET-CT) in stage III melanoma patients. We hypothesize that the increase in vascular inflammation will be greater in the exposure group…

Personalized elective neck irradiation guided by sentinel lymph node biopsy in patients with squamous cell carcinoma of the oropharynx, larynx or hypopharynx with a clinically negative neck: (chemo)radiotherapy to the PRIMary tumor Only. The PRIMO study.

To compare safety and efficacy of treatment with sentinel lymph node biopsy guided elective neck irradiation versus standard elective neck irradiation in patients receiving definitive (chemo)radiotherapy for squamous cell carcinoma of the…

The beneficial value of 18F FDG PET/CT in the follow-up of stage III non-small cell lung cancer patients

Primary Objective The primary objective of this study is to compare the 3-year overall survival of stage III NSCLC patients during follow-up surveillance with 18F FDG PET/CT versus follow-up with conventional CT surveillance. Secondary…

Clinical outcomes and cost-effectiveness of a diagnostic and treatment strategy of upfront CTCA plus selective non-invasive functional imaging compared with standard care in patients with chest pain and suspected coronary artery disease

This strategy will result in a reduction reduce the incidence of major adverse cardiovascular events (MACE) defined as death or non-fatal myocardial infarction and appear more efficient than care as usual.

iPrEx-DISCOVER Weight Change Study

The primary objective of this study is:  To compare weight change/trajectory distributions between F/TAF and placebo cohorts.  The secondary objectives of this study are:  To compare outlier weight gain between F/TAF…

Optimizing parasite transmission to laboratory-reared mosquitoes following controlled human malaria infection with Plasmodium vivax asexual blood stage parasites in malaria-naïve healthy volunteers in the Netherlands

Main objective: Develop a protocol to reproducibly infect mosquitoes with blood from human study participants undergoing asexual blood stage CHMI with the P. vivax clone PvW1.Secondary objectives: Maximize mosquito infection rate with PvW1 by I)…

The social role of menstrual health interventions

Máxima MC is organising this study. The aim of the study is to gain insight into the effect ofdifferent treatments (medication, IUD, endometrial ablation, uterus removal) formenstruation-related complaints on labour and educational participation.…

BOOST - BMI of children with diabetes type 1: a study on the transition to smart technology

The objective is to investigate if AHCL in children with DM1 leads to a greater difference in BMI SDS compared to MDI. The second objective is to study if there is a difference between MDI and AHCL in DM1 regarding blood glucose regulation and…

PSMA Detect

The primary objective of this study is to evaluate the added value of PSMA PET/CT and PSMA-targeted biopsies of PSMA-avid lesions in detecting ISUP GG ≥ 2 prostate cancer in patients with a negative or equivocal MRI (PIRADS 1-3) and a PSA density…

Comparing oxycodone and morphine in relation to long-term opioid use.

The aim of this study is to compare oxycodone and morphine as the first-choice opioid for postoperative pain after orthopedic surgery regarding: The proportion of patients with new long-term opioid use (>6 months). The total proportion of…

A European multicenter, observational study to understand how the use of lebrikizumab affects health-related well-being and disease symptoms in patients with moderate-to-severe atopic dermatitis (ADTrust).

Primary objective: To assess the long-term effect of treatment with lebrikizumab on the overall well-being in patients with moderate-to-severe AD using the WHO-5 questionnaire. Secondary objectives: To assess the clinical effectiveness of…