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perioperative intravenous insulin, GIK and GLP-1 treatment in diabetes mellitus

This study investigates the optimal intraoperative treatment algorithm to lower glucose in patients with diabetes mellitus type 2 undergoing non-cardiac surgery, comparing intraoperative glucose-insulin-potassium infusion, insulin bolus regimen and…

The effect of insulin-induced hypoglycemia on brain lactate accumulation and regional cerebral blood flow, an explorative study

The primary objective of this study is to investigate the effect of hypoglycemia on brain lactate accumulation and regional cerebral blood perfusion in humans. The secondary objective is to assess whether this effect is a related to hypoglycemia…

Open Label Single Period Pilot Clinical Trial to Standardize Procedures for Evaluation of Glucose Dependent Insulin Secretion in Subjects with Type 2 Diabetes Mellitus

To standardize the procedures and analyses to support evaluation of glucose dependent insulin secretion in Type 2 Diabetes Mellitus in subjects with Type 2 Diabetes.

BEGIN: YOUNG 1, trial id: NN1250-3561. A clinical trial investigating the efficacy and safety of insulin degludec in children and adolescents with type 1 diabetes mellitus.

Primary objective: to confirm the efficacy of insulin degludec administered once daily plus mealtime insulin aspart in controlling glycaemia with respect to change from baseline in HbA1c after 26 weeks of treatment. Secundary objective: to compare…

An open-label, crossover study to assess the pharmacokinetics, safety and tolerability of pulsatile intra-vaginal delivery of insulin aspart in females with diabetes mellitus type 1

Primary* To explore the pharmacokinetics of insulin aspart after pulsed intra-vaginal delivery using the MedRing and after subcutaneous injection in women with DM1.Secondary* To assess the safety and short-term tolerability of insulin aspart after…