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The effect of Telmisartan on inflammatory processes in the vascular wall of abdominal aortic aneurysms.

In this study we would like to study the effects of the selective angiotensin II antagonist Telmisartan on inflammation and cell/matrix homeostasis in the human aneurysm aortic wall.

Rotation for Optimal Targeting of Albuminuria and Treatment Evaluation (ROTATE-1)

A better understanding on the individual response to different albuminuria lowering drugs and a better understanding why these drugs, of which some are developed for another indication, may help to tailor optimal therapy. Therefore in this study…

Grasping the Underlying Mechanisms of drug Disposition and Receptor Occupancy by Positron-emission tomography Studies (GUMDROPS):
A feasibility study for the use of 11C-telmisartan to quantify individual differences in target-site exposure in diabetes patients;

Primary objectives:* To assess telmisartan target (i.e. receptor) specific binding in vivo* To assess receptor occupancy of telmisartan in vivo* To determine optimal scanning time in vivoSecondary objective:* To explore the effect of telmisartan on…

A rotation study of different albuminuria lowering drug classes to study individual drug response in diabetes

A better understanding on the individual response to different albuminuria lowering drugs and a better understanding why these drugs, of which some are developed for another indication, may help to tailor optimal therapy. Therefore in this study…