140 results
The aim of this proposal is threefold: (i) test a neuroscientific model of prosocial development by relating neuroscience discoveries to changes in several dimensions of prosocial development in a comprehensive study including children, adolescents…
In this study, the aim is to perform a clinical evaluation of the NovioMini in children during behavioural bladder training to examine the performance of the NovioMini as a full-bladder-based notification system during natural bladder filling.
To establish a healthy control group for microcirculatory parameters for current and future studies on the paediatric microcirculation.
Primary goal:To provide an overview of long term effects (neurocognitive, behavioral and learning problems) in children with MTHI and to identify specific risk groups with a higher prevalence of more serious problems. This knowledge can contribute…
To gain insight into the biological pathways that are influenced by the CEEx30/31 mutations.
The PowerMe study will analyse fatigue characteristics and severity in children and adolescents with mitochondrial myopathy and their families. Then a blended personalized cognitive behaviour therapy program for fatigue will be designed and tested,…
This pilot prospective cohort study is designed to provide feasibility data for a large global study that will critically evaluate the impact of sport activity and FAI development during the critical phase of hip maturation.Primary Feasibility…
1.3. Study Design Rationale The ATLAS-INH trial (ALN-AT3SC-003) is a multicenter, multinational, randomized, openlabel Phase 3 study designed to demonstrate the efficacy and safety of fitusiran in patients with haemophilia A or B with inhibitory…
1. Inventory of the current care of boys/men with Duchenne Muscular Dystrophy in the Netherlands: To establish the extent of implementation of the international guidelines and its updates in the Netherlands and to explore the relationship between…
Primary Objective: Our overall aim is to improve selection of patients for epilepsy surgery and predict surgical candidacy with use of genetic test results as a biomarker. The specific objectivesare:Cohort I1. Apply genetic testing for epilepsy gene…
To examine the feasibility and acceptability, and preliminary efficacy, of a new developed enhanced CBT (eCBT) for pediatric obsessive-compulsive disorder
To validate and assess the impact of the use of the MyCyFAPP system for self-management in children with CF, more specifically the effect on patients* quality of life, nutritional status, gastro-intestinal symptoms, general wellbeing and economic…
This study concerns a pilot implementation and evaluation of FAME. - It aims to provide an initial indication of the efficacy of FAME in families in two living conditions: asylum centers and family locations. It is hypothesized that FAME has a…
The primary objective is to determine the effect of a 8-week inspiratory muscle training program on respiratory muscle function in nemaline myopathy patients. The secondary objective is to determine respiratory muscle function in nemaline myopathy…
The present study aims to examine if BA has a positive effect on the severity of depressive symptoms as measured by the PHQ-9 in adolescent depressive participants. In addition, several additional objectives are included (classification of the…
To visualize and quantify areas of dysfunctional flow in the TCPC and within the single ventricle in patients after a Fontan procedure and try to determine a relationship between these quantitative energetic parameters and adverse outcome.
To explore the nature, disturbed mechanisms and consequences of feeding, mastication and swallowing problems in patients with SMA type II and III, and to describe these problems using instrumental, clinical dysphagia assessments and the LINMA(-k) (…
The primary objective of this study is to investigate the association between smartphone use and risk of myopia in teenagers.
Validation of the Eleveld PKPD model, both the pharmacokinetic component (plasma concentrations) and the pharmacodynamic component (effect: bispectral index (BIS) and predicted effect-site concentrations).
The primary objective of this study is to describe the intracardiac anatomy and hemodynamics of DILV patients without Fontan circulation using 4D MRI. Furthermore, the functional status and quality of life of these patients will be assessed and…