19468 results
The objective of this CPS is to establish the clinical performance of F1CDx as a companion diagnostic (CDx) for AZD0022 in patients with NSCLC, CRC, or PDAC with a KRASG12D mutation. This CPSP will be executed in combination with the clinical trial…
The main (primary) objective is to study the influence of sex on the pharmacokinetics (PK) of metoprolol in patients after CABG with heart valve surgery and patients with a STEMI/NSTEMI who are prescribed a standard dosage of metoprolol as part of…
Primary Objective: To determine how exposure to +5Gz forces affects small airway function when breathing ambient air (21% oxygen) and oxygen enriched air (60% oxygen) , without the breathing component of the AGSMSecondary Objective: To explore the…
The primary objective of this study is to assess the safety and performance of the ABLE Daily to perform ambulatory functions in home and community settings for people with spinal cord injury.The secondary objectives are to assess the impact of the…
1, Quantify and compare vascular and structural parameters obtained from AO-FIO, OCTA, OCT, and CFP in both healthy controls and glaucoma patients; 2, Investigate the correlation between these parameters and assess the additional value of vascular…
To assess the adherence to the intervention regarding successfully followed exercise sessions, adverse events related to the intervention and experiences of intervention supervisors and participants. Secondly, we will evaluate intervention effects…
Primary objective:What is the incidence of an unsafe swallow situation (PAS score >= 6) after decannulation in ICU patients who had a safe swallow situation with a tracheal cannula prior to decannulation (PAS score < 6)?Secondary…
Primary Objective: Assess which digital health metrics are relevant to monitor for patients with (or highly suspected of having) obstructive sleep apnea before and after diagnosis, and during titration of treatment with continuous positive airway…
This study aims to evaluate A-mode ultrasound for assessing JVPW characteristics as a non-invasive tool to discriminate between healthy subjects and those with pulmonary arterial hypertension patients, and to assess if JVPW changes relate to changes…
The primary objective is to evaluate the feasibility of ICG-enhanced near-infrared qFME to determine tumour demarcation and tumour depth in upper GI tumours (e.g. HGD or superficial oesophageal and/or gastric adenocarcinoma (T1)) during ESD.
The REPLACE study aims to determine whether not changing the catheter (catheter retained) for catheter-associated urinary tract infections (CAUTI)affects the recurrence-risk of CAUTI.
To explore whether vigorous endurance exercise (i.e., running a marathon) alters the magnitude of cardiac damage following myocardial ischemia-reperfusion injury in amateur athletes through using an ex vivo rat heart model of myocardial infarction.
Primary objective: - To study the diagnostic accuracy of PCCT (± CT-derived fractional flow reserve [FFRct]) as compared to the reference standard ICA (± FFRinv) in the NSTE-ACS population referred to the UMCG. Secondary objectives: - To study the…
This is a pilot study for investigating the cause of recurring cerebral thrombo-embolic events in a patient after (branched) TEVAR surgery. The main aim of this logistical pilot is to develop a workflow for investigating blood flow patterns in such…
The aim of this study is to better understand the relation between cognition, sensory functions and motor control for speech in older age. Thereby, we strive for improved speech-based discrimination of typical aging from neurodegenerative declines.
Our overall aim is to develop mid-field MRI systems for low-threshold, extramural service to GP practices that can contribute to making healthcare more sustainable. In this study we want to perform the first steps towards this general aim. On one…
In this pilot study, we aim to assess practical feasibility, technical feasibility and safety of a computational approach for programming newly implanted STN-DBS patients with PD. This computational approach will be based on patient-specific sweet…
Intra-arterial pressure measurements are currently the most promising tool to guide clinical decision making in patients with suspected CMI. Implementation of pressure measurements could result in major improvements in quality of life by tailoring…
To evaluate the efficacy of a new tumor-agnostic ctDNA assay, the ctDNA estimator, to detect newly developing tumors in Lynch carriers.
To determine the proportion of travelers and migrants diagnosed with chronic schistosomiasis as per each centre*s routine assessment, who have active infection at presentation (as assessed and classified by composite reference standards integrating…