1692 results
To assess the association between baseline blood pressure and change in neurocognitive functioning after four years, and to assess whether baseline MRI phenotypes are predictive for changes in neurocognitive functioning after four years in the DANTE…
The aim of the study is to expand an existing infrastructure for scientific research, i.e. a longitudinal observational study, for investigating physical, emotional, cognitive and social trajectories of functioning, their determinants and their…
1. To characterize long-term neurologic- and cognitive disorders, audiological and ophthalmological alterations in cCMV-infected children.2. To identify immunological, neurological host factors and virological factors that are predictive of…
Research Questions: Primary:1. Does a single night of short sleep reduce metabolic flexibility following a mixed meal challenge?2. Does a single night of short sleep alter the responsiveness of the HPA-axis?3. Are the disturbances of a single night…
Primary objectivesTo characterize the bone marrow microenvironment in advanced stage myelofibrosis (MF) before and during treatment with ruxolitinib, regarding osteoblastic activity, marrow fibrosis and - osteosclerosis and perfusion- and diffusion…
Main study:We want to assess whether bleeding risk in women with uterine leiomyomas is associated with CK activity and attenuated platelet aggregation.Objective of pilot study:Firstly, to perform a feasibility pilot of CK/AK measurement in menstrual…
Objectives: 1. To assess the prevalence of pain in elderly with dementia and to study the relationship between the various subtypes of dementia and the presence of specific types of pain(e.g. nociceptive pain, neuropathic pain, and orofacial pain).…
In patients with NSTEMI we aim to: 1) compare coronary vulnerable plaque detection between 18F-NaF-PET-CMR and invasive coronary angiography, 2) investigate the relation of coronary vulnerable plaques using 18F-NaF-PET with myocardial infarction…
Primary objectives:- To investigate possible differences in driving performances between premanifest gene carriers, manifest HD, and control subjects.- To explore if different aspects of cognitive functioning might be a predictor of fitness to drive…
This study aims at, first, assessing the most relevant exposure aspects of night-shift work and, second, identifying biomarkers for both acute and chronic circadian disruption associated to these specific nightshift work aspects. By applying…
The main objective of this study is to compare levels of stress reactivity, social anxiety and cortisol in daily life between adults with ASD and healthy controls. Besides, fluctuations and interactions of these variables over time and their…
The overall objective of this study is to develop patient friendly and unobtrusive techniques to characterize motor function. In this context we will use video cameras combined with depth sensors (RGB-D sensors, such as Microsoft KinectTM) and…
Primary Objective:Pilot study: Selection of the titanium derivatives which are capable of penetrating the skin, and thus can be used in the full study as patch test materials.Full study: To compare the results of three different diagnostic tests…
Hypothesis: gaseous signaling molecules influence placental vasomotor activity to compensate for hypoxemia. Metabolites of these vasoactive molecules can be found in the blood and urine and can indicate whether this (compensatory) mechanism is used…
The aim of this study is to determine whether male microchimerism is present in patients with MRKH syndrome. This would be a sign of intrauterine cell trafficking - and possible AMH transfer- from male to female co-twin. This placental blood…
The primary objective of the study is to determine whether patients with PA have a higher level of arterial wall inflammation than patients with essential hypertension. Secondary Objectives: To determine whether circulating monocytes of patients…
The aim of this study is to evaluate the long-term imaging and functional outcomes of overuse injuries of the wrist in (former) athletes.
The primary objective of this study is to predict the antidepressant treatment outcome of ECT in patients with severe depressive symptomatology using neuroimaging. ECT itself is conducted as usual according to national guidelines (Nederlandse…
Describe the relation between patterns in biomarkers of vascular inflammation, plaque instability and hypercoagulability and the incidence of recurrent ACS
We aim to gain insight into the incidence and severity of CIPN and its influence on patient-reported outcomes (i.e. health related quality of life (HRQoL), disease-specific complaints, depression, fatigue, sleep problems) among a prospective…