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Longitudinal Aging Study Amsterdam, a solid infrastructure for the social science of ageing in the oldest-old

The aim of the study is to expand an existing infrastructure for scientific research, i.e. a longitudinal observational study, for investigating physical, emotional, cognitive and social trajectories of functioning, their determinants and their…

Sample collection for assessment of variability of metabolite and protein biomarkers in healthy male volunteers

Collection of blood and urine samples for estimation of the metabolomic and proteomic intra- and inter-subject variation for an extensive set of biomarkers in healthy male volunteers.

89Zr-AMG211 PET imaging in patients with relapsed/refractory gastrointestinal adenocarcinoma before and during treatment with AMG 211.

Primary objective: To evaluate the in vivo biodistribution (measured in SUV) and quantitative radioactivity in organs of 89Zr-AMG211 in patients with relapse/refractory gastrointestinal adenocarcinoma as assessed by PET/CT. Secondary objectives: I)…

Markers for neurocognitive impairment in congenitally CMV infected infants: MARVELYS study

1. To characterize long-term neurologic- and cognitive disorders, audiological and ophthalmological alterations in cCMV-infected children.2. To identify immunological, neurological host factors and virological factors that are predictive of…

Neuropsychological assessment in X-linked adrenoleukodystrophy

The primary objective is to assess neuropsychological function in X-ALD patients without active cerebral demyelinating disease. Data of minors will be compared to matched healthy controls. Data of adults will be compared to reference values. The…

Biomarkers of the HIV reservoir

Primary objectivesLongitudinal quantification of the total latent HIV reservoir with determination of the size of the replication competent HIV reservoir and investigate potential biomarkers of the HIV reservoir size and nature.Cross compare the…

Pilot study 'Mindfulness for people with burns and parents of children with burns: feasibility and potential effect of a first mindfulness training'

Aim of the study is exploring the feasibility and potential effect of a Mindfulness training for people with burns and parents of children with burns.

A novel method to assess VO2max in a respiration chamber

The current study aims to develop a novel approach to assess VO2max without any breathing restriction at the mouth by measuring maximal oxygen uptake in a respiration chamber.

DEfective HUman SAlivary gland stem cells: the cause of Primary Sjögren*s syndrome?
-DEHUSAPS study-

To assess whether salivary gland stem cell (SGCS) defects are key to salivary gland pathogenesis in pSS.

An Open-Label Safety Extension Study to a Multicenter Study of Liposomal Amikacin for Inhalation (LAI) in Adult Patients with Nontuberculous Mycobacterial (NTM) Lung Infections caused by Mycobacterium avium complex (MAC) That are Refractory to Treatment

Primary Objective To evaluate long term safety and tolerability of LAI (590 mg) administered once daily (QD) for up to 12 months in subjects who were refractory to standard multi-drug treatment and failed to convert in Study INS-212. Secondary…

Think different. A study into the feasibility and the effectiveness of an online Cognitive Bias Modification training on an app for adolescents with an obsessive compulsive disorder (OCD)

This study concerns research into the applicability and effectiveness of CBM-I training through an app on the mobile phone. The research is done in adolescents (12-18 years) treated at the Bascule clinic for OCD. The training will take place during…

Needle based CLE in thoracic lymph nodes, a comparison with pathology.

To identify and define characteristics of healthy lymph nodes and lymph nodes involved in different pulmonal diseases (lungcancer and sarcoidosis)

The effects of pregnancy on the human brain

The proposed study will further examine the effects of pregnancy on the human brain, by investigating structural and functional connectivity, local metabolite concentrations and neural activity related to social cognitive and memory processes.…

Mental imagery in women with eating disorders and healthy controls.

Primary Objective:First we need to establish that patients with an eating disorder and healthy controls differ in mental imagery. So, the first aim of our research is to compare the nature and characteristics (emotionality, vividness and perspective…

A Phase 3 Multicenter, Multi-dose, Open-label Maintenance Study to Investigate the Long-term Safety and Efficacy of ZS (Sodium Zirconium Cyclosilicate), an Oral Sorbent, in Subjects with Hyperkalemia

Primary objective of this trial is to generate open-label, long-term (up to 12 months) safety and tolerability data for ZS in subjects with hyperkalaemia (S-K * 5.1 mmol/L)Secondary objectives:* To evaluate the portion of ZS-treated subjects in whom…

Compulsivity in gambling disorder and obsessive-compulsive disorder: a functional magnetic resonance imaging (fMRI) study

Investigating and comparing two disorders (i.e., OCD and GD) with phenomenological different types of compulsive behaviors central to their pathology can elucidate common mechanisms of compulsivity in psychiatry - core features- as well as specific…

Probing the role of sodium channels in painful neuropathies (PROPANE Study)

To investigate whether sodium and potassium mutations are found in a cohort of patients with small fiber neuropathy, painful diabetic neuropathy (versus diabetes patients with no or only minor symptoms) and in patients with breast, ovarium or…

neoMONARCH: A Phase 2 Neoadjuvant Trial Comparing the Biological Effects of 2 Weeks of Abemaciclib (LY2835219) in Combination with Anastrozole to those of Abemaciclib Monotherapy and Anastrozole Monotherapy and Evaluating the Clinical Activity and Safety of a Subsequent 14 Weeks of Therapy with Abemaciclib in Combination with Anastrozole in Postmenopausal Women with Hormone Receptor Positive, HER2 Negative Breast Cancer

The primary objective of Study I3Y-MC-JPBY (JPBY) is to compare the biological activity ofabemaciclib in combination with anastrozole, abemaciclib monotherapy, and anastrozole monotherapy byassessing the percentage change from the baseline value in…

18F-FDG PET/CT versus CT imaging in staging of primary Muscle Invasive Bladder Cancer

The purpose of this prospective study is to evaluate the value of 18F-FDG PET/CT and CT for preoperative regional N staging of bladder cancer and to verify the results by comparison with histopathological analysis, the gold standard.

Real-time Quantitative Optical Perfusion Imaging in Surgery: A Prospective, Observational, In-vivo, Human, Single-Center Study.

Primary objective- To assess the reliability and explore the validity of Fluorescence Imaging, Laser Speckle Contrast Imaging, Optical Coherence Tomography and Sidestream Dark Field as a perfusion imaging modality, during free flap reconstruction…