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Walking the Isobole of drug Interaction: Comparison of hemodynamic effects, cerebral and tissue oxygenation for 4 equipotent combinations of propofol and remifentanil

To investigate the effects of the different combinations of propofol and remifentanil on the isobole of TOL90 and to compare hemodynamics, cerebral and tissue oxygenation for each equipotent combination. To describe the combination of propofol and…

THE PHARMACOKINETIC AND PHARMACODYNAMIC INTERACTION BETWEEN PROPOFOL AND KETAMINE WHEN GIVEN FOR SEDATION AFTER CARDIAC SURGERY
IN THE INTENSIVE CARE UNIT.

1. To quantify the influence of propofol on the distribution, redistribution and elimination of ketamine and to evaluate the importance of hemodynamic parameters on the pharmacokinetics of ketamine.2. To quantify the influence of ketamine on the…

Detection of stress in newborns during intubation by means of skin conductance measurements.

Determining the effectiveness of commonly used premedicating agents in reducing subclinical stress responses in newborns during intubation.

A Phase 1, Single-Center, Single-Blind, Placebo and Propofol Controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Ascending Intravenous (IV) Infusion Doses of ABP-700

Primary objectives:- to assess the safety and tolerability of a single ascending intravenous (IV) infusion doses of the research medication.- to determine the maximum tolerated dose (MTD) of IV infusion doses of the research medication.Secundary…

A Randomized, Single-blind, Propofol-controlled Phase III Study Evaluating the Efficacy and Safety of Remimazolam in General Anesthesia in Adult Patients Undergoing Cardiac Surgery, including Follow-up Sedation in the Post-anesthesia Care Unit / Intensive Care Unit

The objectives are:* to show non-inferiority of remimazolam compared with propofol in terms of successful maintenance of sedation defined as a Narcotrend index of 60 or less during at least 85% of the maintenance time without the use of rescue…

Phase III confirmatory efficacy and safety trial of remimazolam (CNS7056) compared with propofol for intravenous anaesthesia during elective surgery

Primary ObjectiveThis is a confirmatory trial to establish non-inferior efficacy of remimazolam compared with propofol for induction and maintenance of GA for the purpose of elective surgery in patients classes III and IV based on the American…

Volatile Anesthetic Protection Of Renal transplants 2

To compare the effect of a sevoflurane based anesthesia versus a propofol based anesthesia on acute rejection and outcome in recipients of living, DCD and DBD donor kidneys.