17 results
The primary objective is to determine the safety and tolerability BCG vaccination followed by controlled human malaria infection; and to determine the protective efficacy BCG vaccination against a controlled human malaria infection.
1) To evaluate the efficacy of knee-ankle-foot orthoses (worn by night) in preventing a decrease of range of motion to ankle dorsiflexion in children with cerebral palsy (Clinical part). 2) To evaluate the effect of night-worn knee-ankle-foot…
An information campaign was developed targeting early-stage KHOA patients and healthcare professionals (HCPs) to optimise timing of referral to secondary care.
The current study has two aims. Firstly, to investigate the effectiveness and cost-effectiveness of 8 weeks of the E-health program, Featback, in comparison to Featback with online support from an expert patient, online support from an expert…
The objective is:(1) To test the efficacy of VRE versus CAU in 200 children undergoing surgery on the anxiety level of the child during induction of anesthesia (primary outcome), pre- and postoperative child anxiety, pre- and postoperative parental…
To compare the effect of two automated oxygen controllers (Oxygenie and CLiO2) on time spent within oxygen target range in preterm infants.
The primary objective is to investigate whether (and if so, which) type of CBT-element (cognitive restructuring (CR), behavioral activation (BA), relaxation (RE) and problem solving skills(PS)) is relevant for the positive effect of CBT-programs on…
To evaluate the efficacy of laxatives (polyethylene glycol) versus supplementation of fibers on the incidence of rebleeding in patients hospitalized for colonic diverticular bleeding.
Primary Objective: Measure QoL (VEINES QoL/Sym) change in patients with DVO at one year after PTA and stenting compared to conventional therapy (short class II elastic compressions stockings, exercise, lymph drainage therapy and the use of (pain)…
Main objective: to test the effectiveness of KOO-PTSD on parenting skills at the macro- and micro-level.Secondary objectives: to test the effectiveness of KOO-PTSD on perceived parenting competence, social support, parenting stress, child…
To study the possible epigenetic modifications in sperm cells after BCG vaccination
The objective of the study is investigate the relationship between adherence to the recommendations for cancer prevention of the WCRF and cancer-related fatigue in colorectal cancer survivors.
In this intervention study, the primary aim is to evaluate the influence of E171 exposure on the gene expression profile in rectal biopsies. In addition, inflammatory markers such as ROS in the rectal epithelium will be measured as secondary outcome…
Primary objectives1. To determine if BCG vaccination (Intervention) compared with placebo (Comparator) reduces the incidence of COVID-19 disease (Outcome) measured over the 6 months following randomisation (Time) in healthcare workers exposed to…
Primary Objective: The aim is to evaluate, among in a group of systemically and periodontally healthy subjects, the effect of four different (commercially available) oral mouthwashes with intra-oral halitosis. In particular, what is the effect of…
The main objective will be to investigate whether treatment with nVNS on top of best medical practice in acute ischemic stroke patients results in smaller infarct volumes compared with the infarct volumes of patients not treated with nVNS.
Primary Objective: To establish that ACT guided heparinization results in safe and optimal anticoagulation during open AAA repair. We hypothesize that ACT guided heparinization will result in a decrease of thrombo-embolic complications, without a…