20 results
To gain further insight into the interaction and possibly shared pathophysiological mechanisms of female-specific cardiovascular risk factors and events we will quantify white matter hyperintensities on brain MRI and assess endothelial function in…
To characterize the glycaemic and insulinaemic responses of regular camel milk and camel milk powder in healthy adults.
The main objective of the present study is to test 1) whether paranoid anxiety moderates the relation between rejection and aggression, and 2) whether social anxiety moderates the relation between rejection and withdrawn behavior.
1. Randomised controlled determination of the influence of foods on the behaviour of a heterogeneous not-selected group primary school children, during the first two months of the trial. 2. Determination of an IgG or IgE-mediated respons to foods,…
This study aims to define the role of the IEC in S. aureus colonisation.
The aim of the present study is to test whether there is a causal relationship between expectancies regarding the effect of eating on mood, changes in mood and actual caloric intake. In order to test whether there is a causal relationship between…
The main objective of this study is whether EMDR is an appropriate treatment for women with PTSD after a previous birth. The resulting hypotheses are that at the two follow-up meaurements, in relation to the pretreatment-measurement 1) WITHIN the…
Main objectieve of this study is if EMDR is an effective treatment for women with FoC. Our hypotheses are that in follow-up measurement compared to the pretreatment-measurement 1) WITHIN the treatment group there will be a decrease in the severity…
The study is primarily designed to compare the clinical outcome between the TM transfer and the LD transfer in patients with a massive posterosuperior rotator cuff tear. Our secondary objective is to asses the quality of life in patients undergoing…
Objectives: 1) The development of an optimal point-of-care (POC) breath test for an early asthma diagnosis in preschool wheezing children; 2) To unravel important pathogenetic mechanisms in the early development of viral wheeze and asthma by…
To study the effects of post-ingestion nutrients on brain activity and brain dopaminergic responses in lean subjects, and in obese subjects before and after diet-induced weight loss.
The primary objective of this study is to examine clinical and radiographical parameters when executing:- adjuvant antibiotic therapy versus no antibiotic therapy in the resective surgical treatment of 0-, 1- and 2-wall bone defects due to peri-…
6.2.1 Primary objective The primary objective is to assess the effectiveness of a stepwise medical therapy approach guided by coronary function testing in reducing angina burden of patients with angina pectoris and no obstructive epicardial coronary…
This study aims to assess if actively training adductor co-contraction in patients with SAPS is clinically effective. A specific therapy protocol is already in practice in the physical therapy department of the Leiden University Medical Center (LUMC…
Primary objective:To deliver an easy accessible, patient friendly and low-cost self-help intervention for the treatment of depressive symptoms in dialysis patients.Main hypothesis: An eHealth CBT intervention reduces depressive symptoms in dialysis…
The overall aim of this study is to gain insight into the pathophysiological mechanisms behind cervical radiculopathy and determine if conservative treatment targets these processes. Different research questions are formulated:1) Is there any…
To analyze how potassium handling, volume and sodium status change in stable anuric chronic hemodialysis patients (CKD-5D) in response to higher dialysate potassium.
To develop a *two hit* in vivo autologous PLTs transfusion model in healthy male volunteers
To understand if handsewn (end to end and Kono S side to side) anastomoses is superior to side to side stapled anastomosis after ileocolic resection for Crohn's disease with respect to endoscopic recurrence, gastrointestinal function and costs.
We intend to perform a pilot study to determine the optimal nutrient mix (predominantly based on medium-chain triglycerides, MCTs) to induce a mild ketogenic state in healthy older (60-80y), overweight/obese (BMI: 25-35 kg/m2). Since the aim is to…