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The effects of attachment and emotion regulation on depression and anxiety

Aim of this study is to examine the mechanisms by which attachment style and emotion regulation relate to depressive symptoms and anxiety symptoms in a clinical and non-clinical Dutch population.

A prospective randomised Rontgen Stereophotogrammatic Analysis (RSA) study using the uncemented Trident Tritanium acetabular component and the uncemented HA coated Symax hip stem in a single centre.
Assessment of implant migration, bone remodeling and clinical function.

The goal of this clinical investigation is to assess the early migration and bone remodeling of the Symax hip stem and the Trident HA coated or Trident Tritanium acetabulum component with RSA and 18-F PET CT Also the sensitivity of the RSA…

Dorsal spondylodesis in adolescent idiopathic scoliosis: proximal fixation with screws versus claw construct

The main objective is to compare the coronal Cobb angle correction of proximal hook claw fixation versus proximal pedicle screw fixation after two years of follow-up. The secondary objectives of the study are: comparison of coronal Cobb angle…

The hysteroscopic morcellator versus the bipolar resectoscope for removal of residual placental tissue: a randomized controlled trial.

To compare the HM to bipolar resectoscopy for removal of residual placental tissue in terms of efficiency and complications.

Pre-pain rehabilitation (PREPARE) treatment in chronic pain: a randomized controlled trial (RCT)

1. What is the effectiveness of MIP (MI-based pre-treatment) compared to UC (usual care) on the level of participation and treatment drop-out in patients with chronic non-specific musculoskeletal pain following pain rehabilitation?2. What is the…

Prevention of CF exacerbation in childhood (PREVEC-study): early recognition by non-invasive biomarkers in exhaled breath (condensate) and early antibiotic treatment

To assess the efficacy of an intervention directed towards prevention of clinical CF exacerbations by means of early recognition and early antibiotic treatment.

The hysteroscopic morcellator versus the bipolar resectoscope for removal of larger intrauterine polyps: a randomized controlled trial.

To compare the HM to bipolar resectoscopy for removal of large intrauterine polyps in terms of efficiency and complications.

Randomized Study of IN.PACT Amphirion* Drug Eluting Balloon
(DEB) vs. standard PTA for the treatment of below the knee critical
limb ischemia [IN.PACT DEEP]

1. Evaluate safety and clinical and angiographic efficacy of BTK revascularization with IN.PACT Amphirion* randomized to standard, uncoated PTA balloons2. Assess the clinical efficacy of BTK revascularization with IN.PACT Amphirion* compared to a…

Central effects of endogenous GLP-1 and the GLP-1 analog liraglutide on brain satiety and reward circuits and feeding behavior in diabetes.

The objective of the study is to gain insight in the role of endogenous GLP-1 on food-stimuli related CNS satiety and reward responses and the alterations between lean and obese-T2DM individuals. Also, to gain information about treatment with a GLP-…

A clinical evaluation to compare the safety, efficacy and performance of
ABSORB everolimus eluting bioresorbable vascular scaffold against
XIENCE PRIME everolimus eluting coronary stent system in the
treatment of subjects with ischemic heart disease caused by de novo native
coronary artery lesions

To compare the safety, effectiveness and performance of TM ABSORB bioabsorbable everolimus eluting vascular scaffold against XIENCE PRIME TM everolimus eluting coronary stent system in treating people with ischemic heart disease caused by de novo…

A prospective, randomized, multicenter, interventional study to evaluate the safety and effectiveness of the TactiCath® percutaneous ablation catheter for the treatment of symptomatic paroxysmal atrial fibrillation using contact force assisted irrigated radiofrequency ablation

Effectiveness: To provide valid scientific evidence that use of the TactiCath® Set is an effective treatment for symptomatic paroxysmal atrial fibrillation (PAF).Safety: To provide valid scientific evidence that use of the TactiCath® Set is safe as…

The ClariVein device using 2% and 3% liquid Polidocanol for the treatment of great saphenous vein incompetence

Our study tries to identify the ideal sclerosant dosage for the ClariVein® system in order to occlude the GSV permanently. By choosing the lowest dose with the same anatomical success rate, we achieve a safe treatment which also gives us the…

Treatment of Fatigue in Multiple Sclerosis: Aerobic Training, Cognitive Behavioural Therapy, Energy Conservation Management

To determine whether rehabilitation treatment strategies effectively reduce fatigue and improve participation in MS patients with fatigue, and how they exert their effects.Research questionsQ1) Does AT result in reduced fatigue and improved…

Fluoroscopy in hipsurgery: Does manual control of the fluoroscope by the traumasurgeon lead to shorter fluoroscopy time?

To determine wether surgeon-controlled fluoroscopy leads to a lower fluoroscopy time, during placement of osteosynthesis material in hip fractures.

The influence of different restorative materials on recurrent caries lesion formation and on plaque acid formation and composition.

To determine the difference in secondary caries lesion development in tooth samples with simulated restorations from different restorative materials and to relate this to the microbial composition and acid production capacity of biofilm taken from…

A Multi-centre, Single-blind Trial Evaluating Safety and Efficacy, including Pharmacokinetics, of NNC-0156-0000-0009 when used for Treatment and Prophylaxis of Bleeding Episodes in Patients with Haemophilia B

Primary Objective: To evaluate the immunogenicity of N9-GP.Key Secondary Objectives: * To evaluate clinical efficacy of haemostasis (treatment of bleeding episodes) of N9-GP.* To evaluate clinical efficacy of N9-GP in long term bleeding prophylaxis…

Determining the Feasibility of Spinal Cord Neuromodulation for the Treatment of Chronic Heart
Failure

To evaluate whether spinal cord stimulation is benificial for chronic heart failure patients

Mindfulness-Based Cognitive Therapy (MBCT) and Cognitive Behavioral Therapy (CBT) for depression in patients with diabetes: a randomized controlled trial

Primary Objective: To assess immediate and long-term effects of Mindfulness-based Cognitive Therapy (MBCT) and Cognitive Behavioral Therapy (CBT) in reducing depressive symptoms in patients with diabetes. Regarding immediate effects, we expect that…

Preoperative selection and conditioning of patients with esophageal cancer

Primary Objectives:This study consist of:1) a prospective cohort study in which all patients with esophageal cancer, selected for esophagectomy, and willing to be included in this cohort, are followed to assess their complications, short en long…

A phase I, single-centre, randomised, single-blinded, placebo-controlled single ascending dose study, followed by an open-label extension, evaluating the safety, pharmacokinetics, pharmacodynamics and efficacy of ALX 0651, administered intravenously to healthy male volunteers.

The objectives of this study are to:* To establish the safety and tolerability of ALX 0651, administered i.v. to healthy volunteers.* To investigate the pharmacokinetics of ALX 0651, administered i.v. to healthy volunteers.* To investigate the…