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Costs of Implant-supported Over-Dentures (IOD) can be halved using a digital workflow

Our goal is to manufacture a 3D-IOD which is designed digitally, and subsequently 3D-printed. Such 3D-IOD, can be made cheaper, faster and more patient friendly. To prove such a statement, patients should at least be even satisfied about their 3D-…

Cognitive behavioral therapy for Misophonia, RCT

To evaluate the effect of the CBT groep treatment for misophonia.

Core elements of Cognitive Behavioral Therapy in preventing depression in youth:
Does the type and sequence of elements matter?

The primary objective is to investigate whether (and if so, which) type of CBT-element (cognitive restructuring (CR), behavioral activation (BA), relaxation (RE) and problem solving skills(PS)) is relevant for the positive effect of CBT-programs on…

Acetazolamide in Aneurysmal Subarachnoid Hemorrhage

In a phase II study we will evaluate safety and proof-of-concept of acetazolamide in patients with aneurysmal SAH. The primary aim of this study is to evaluate whether acetazolamide improves cerebral perfusion as measured with magnetic resonance…

Efficacy, safety and tolerability of a bowel cleansing preparation (Eziclen®/Izinova®)
in paediatric subjects undergoing colonoscopy: a Phase III, multicentre, randomised, comparative study versus Klean-Prep® (PEG-Electrolytes), administered on the day before colonoscopy,
Investigator-blinded, non-inferiority in adolescents of 12 to 17 years of age (inclusive) > 40 kg.

Primary objective:To demonstrate that Eziclen, given on the day before colonoscopy has non-inferior efficacy to Klean-Prep on colon cleansing in adolescents aged 12 to 17 years (inclusive) with a body weight > 40 kg, scheduled to undergo a…

A COGNITIVE BEHAVIOURAL GROUP PROGRAMME - PLUS FOR WOMEN WITH DYSPAREUNIA: A RANDOMIZED WAITING LIST CONTROLLED MULTI-CENTER TRAIL OF EFFICACY

Primary objective: to evaluate whether the group programme-plus improves pain during intercourse in women with superficial dyspareunia compared to women in a waiting-list control condition.

Effect of a banded extended pouch in aRoux-en-Y gastric bypass

To investigate the effect of a banded-extended RYGB on weightloss and weigtregain on the long term.

Back2Action: Physiotherapy enriched with an eHealth psychological intervention for patients at risk of developing persistent low back pain or neck pain

To study the effectiveness of physiotherapy plus an eHealth psychological intervention targeted at psychosocial risk factors compared to usual physiotherapy care on disability, for patients at risk of developing persistent low back pain and neck…

Blended versus face-to-face Cognitive Behavioural Therapy in treating severe fatigue in patients with MS - an observer-blinded randomized clinical trial testing non-inferiority at post-treatment and long-term effectiveness.

1. To investigate the non-inferiority of blended CBT compared to proven effective face-to-face CBT according to the TREFAMS-CBT treatment protocol in severely fatigued patients with MS, using a non-inferiority margin of 5.3 points on the Checklist…