301 results
(1) To compare adenoma miss rates (AMR) between Endocuff Vision-assisted colonoscopy (EAC) and conventionalcolonoscopy (CC)(2) To compare adenoma detection rates (ADR) between EAC and CC(3) To assess whether a proposed increased ADR and reduced AMR…
The randomized controlled trial (RCT) will be performed at Karakter Child and Adolescent*s Psychiatric Hospital and will be implemented at all locations, spread out over three provinces in The Netherlands. The project aims:1. To explore the…
To investigate whether perturbation of the left middle temporal gyrus results in immediate adaptation in the right hemisphere, indexed by a shift of alpha-beta oscillatory effects from the left to the right hemisphere.
We presume that reducing the fasting period by adding a carbohydrate drink 2-3 hours prior to surgery is a good and feasible option to decrease orthostatic intolerance and -hypotension. Moreover, the pre- and postoperative well-being is thought to…
The hypothesis is that low dose GC therapy exerts its anti-inflammatory effect by virtue of a first-pass effect through the liver. It is difficult to directly address the hypothesis, but there is an indirect way of doing so: if indeed low dose GCs…
The aim of this study is to investigate the effect of the implementation strategy on level of implementation of palliative care and the effects on patient, informal caregiver and professional outcomes. It is hypothesized that implementation of…
To evaluate the effectiveness of eccentric calf muscle exercise therapy compared to strength training of the upper extremities (control group) in patients with chronic midportion Achilles tendinopathy.
Appropriate use and prescription of a lower limb prosthesis for people with leg amputation through or above the knee, can increase the efficiency of the integrated care around the leg prosthesis.
The hypothesis states that the time tom complete an emergency airway with Cricath device is significant faster than with Quicktrach device, which will be studied on porcine cadaver models. In the second outcome, the hypothesis states that there is…
Discontinuation of first-line disease modifying medication (DMT) in patients with relapsing-onset multiple sclerosis that are inflammatory stable for at least 5 years, can be safely done without the return of inflammatory activity.
This study aims to apply state-of-the-art immune tests quantifying the immunosuppressive state in individuals, and the relationship between these pharmacodynamic tests and the pharmacokinetic profile (in whole blood and intracellular) after a single…
The effectiveness and cost-effectiveness of treatment with systemic cyclosporine or dupilumab in children with moderate-to-severe atopic dermatitis is different for patients with low NMF (corresponding with filaggrine-gene mutation) versus children…
Validity: 1.) Correlation between total score of the questions about the construct "function" from the GNAKPS10-16 and the PSK in a group of 10-17 year old children with Osgood-Schlatter is equal to or higher than 0.70 with a p-…
Atherosclerosis is characterized by a persistent inflammation of the arterial wall. Monocyte-derived macrophages are the most abundant immune cells in atherosclerotic plaques. It has recently been shown that not only immune cells of the adaptive…
Children in the game-based intervention condition will improve more on reading fluency than those in the standard intervention (TUA) condition.
(1) patient self-monitoring is not inferior to standard of care in terms of DAS 28 score; (2) patient self-monitoring in RA patients will reduce outpatient clinic visits, and will consequently decrease healthcare costs.
We hypothesize that the subpopulation of CD68+Tie2+ macrophages is increased in diabetic patients in comparison to non-diabetic individuals. These macrophages may cause an increased expression of Ang2 in plaques, thereby enhancing angiogenesis which…
We expect that with a target of 1.5-2.0x baseline aPTT or with LMWH the primary composite endpoint will be reached in 60% of patients compared to 70% in usual care. To show non-inferiority with a significance level (alpha) of 5%, power of 80% and a…