134 results
To study whether polytherapy (methotrexate plus sulfasalazine plus hydroxychloroquine) results in more patients with inactive disease and therefore less patients who need treatment with a TNF inhibitor after 6 months of treatment compared to primary…
The objectives of this study are to (1) test the efficacy of sVRE versus CAU in 180 children undergoing surgery on the postoperative pain of the child (primary outcome), postoperative analgesics use, anxiety level of the child during induction of…
The aim of this study is to determine if mindfulness-based early intervention reduces internalizing symptoms in help-seeking youth and prevents their development into (serious) psychiatric illnesses. In addition we will examine putative changes in…
Our primary objective is to test the effects on researcher-rated severity of PTSD symptoms of a full dose of prolonged exposure therapy (PE), eye movement desensitization and reprocessing therapy (EMDR), cognitive restructuring therapy without…
The aim of the study is:1) To test the effectiveness and cost-effectiveness of KIT for adolescents with (s)PTSD and comorbid symptoms. 2) To compare the outcomes from the current study with outcomes we have collected in two previous randomized…
Primary Objective: To test whether the Feeling Safe-NL programme is more effective in improving wellbeing over time than CBTp (from baseline to 18-month follow-up).Secondary objectives: To test whether the Feeling Safe-NL programme is more effective…
Primary Objective: • To determine the safety profile of long-term vedolizumab IV treatment in pediatric subjects with UC or CD.Secondary Objectives:• To determine the effect of long-term vedolizumab IV treatment on time to major inflammatory bowel…
The objective of this study is to1) validate a specific Selective Mutism Questionnaire (SMQ) to screen adequately for selective mutism; 2) test the effectiveness of an innovative treatment protocol for selective mutism.
To determine the effect of early and intensive motor training on motor function in people with spinal cord injury (SCI).
The goal of this study is to assess the long-term impact on child*s cognitive- en neurodevelopment, growth and health in children born from mothers with preterm prelabor rupture of membranes (PPROM) between 34 and 37 weeks* gestation.
Primary objective:To demonstrate that Eziclen, given on the day before colonoscopy has non-inferior efficacy to Klean-Prep on colon cleansing in adolescents aged 12 to 17 years (inclusive) with a body weight > 40 kg, scheduled to undergo a…
The primary goal of this study is to evaluate whether exposure in big steps is more effective than a small step-by-step approach. The secondary goal is to find child, parent and therapist factors that possibly relate to the effectiveness of the…
To prevent or postpone relapse of anxiety and depression in youth and young adults, with StayFine; a guided app-based modular intervention. Secondary objectives are to explore the effect on other relevant outcomes and to study potential moderators…
Primary Objective: -To investigate whether there is a difference in the Self-management and Transition to Adulthood with Rx (treatment) (STARx) questionnaire score at t=12 months minus the score at t=0 in group YT compared to group O.Secondary…
Primary Objective: To conduct a randomized controlled trial (RCT) to investigate the effectiveness of an online intervention in reducing depressive symptoms (as measured by the simplified PHQ-9) in COPMI between ages 10 to 26 years old.Secondary…
Primary Objective: To evaluate the feasibility and acceptability of the culturally and contextually adapted WHO*s PM+ intervention for Arabic, Tigrinya and Ukrainian speaking refugee youth living in the Netherlands.Secondary Objective:1. To evaluate…
Therefore, the main purpose of this study is to investigate whether this online intervention can indeed help prevent suicide attempts. In addition, we want to examine whether the intervention affects thoughts of suicide, quality of life and broader…
CIRCUS cohort:This study aims to provide a framework to assess the effect of (eHealth) interventions and generate short- and long-term data on clinical and patient-reported outcomes of asthmatic children using a cohort multiple Randomized Controlled…
In a randomised setting we want to investigate wheter we can reduce anxiety and pain in children that need an IV catheter by using a 360 Virtual Reality video in preparation of the actual needle placement.
To test whether the Emma-app and/or a financial incentive can improve therapy adherence, clinical disease outcomes and quality of life in adolescents and young adults with a chronic health condition.