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Low-flow extra-corporeal CO2 removal and 4 mL/kg tidal volume vs. 6mL/kg tidal volume to enhance protection from ventilator induced lung injury in acute lung injury: a randomized multi-center trial

Lower tidal volumes in order to reduce VILI and days on the ventilator which will reduce the number of days on the ICU

Is taxing working memory effective in reducing dental anxiety?

The purpose of this study is to determine whether playing the computer game Tetris® prior to dental treatment is capable of reducing trait anxiety in patients suffering from a severe form of dental anxiety. Patients who visist a dental fear clinic…

Acute neurocognitive and postural effects of Galvanic Vestibular Stimulation

The main objective of this study is to gain more insight into the possible role of the vestibular system in the observed acute effects on neurocognitive and postural stability due to movement in the static magnetic stray fields of MRI scanners. In…

Attention Defficity Hyperactivity Disorder and fMRI neurofeedback: A randomized controlled trial on the effects of self-modulating anterior cingulate cortex activation levels.

The principal objective of this study will be to critically evaluate if the fMRI-neurofeedback training is successful in reducing ADHD symptoms and improving cognitive functioning. Thus, the first goal is to show that ADHD patients are able to…

Implementation of a Transcutaneous Bilirubinometer among Newborns: A Randomized Controlled Trial

To optimize the quality and cost-effectiveness of care for jaundiced neonates in the Isala Klinieken.

Effect of deep neuromuscular block and variations in arterial PCO2 on the surgical rating scale, extubation conditions and postoperative conditions following reversal with sugammadex

To assess whether the implementation of a deep neuromuscular block (NMB) (PTC 1-2) combined with induction of relative hypocapnia creates optimal surgical conditions as measured by the surgeon (using the 5-point Leiden surgical rating scale) versus…

Cue exposure training for overweight children

The primary objective of the present study is to investigate the effectiveness of two intensive two-session trainings, the conventional psycho-education and food cue exposure, on eating in the absence of hunger, binge eating and Body Mass Index (BMI…

Surgical CorrecTion of the Intra MetataRsal Angle In Hallux Valgus, Modified Chevron versus Scarf OsTeotomy

The purpose of this study is to evaluate if the modified chevron is equally effective in correcting the IMA as a Scarf osteotomy. The secondary objective is whether a better function and a lower complication rate can be obtained with a modified…

Effect of a soft rubber bristles interdental cleaner compared to an interdental brushes on dental plaque, gingival bleeding and gingival abrasion in a split- mouth experimental gingivitis model

What is the gingival healing effect of a rubber bristles interdental cleaner compared to an interdental brushes after an 3-week non-brushing period (experimental gingivitis) measured with the Bleeding on Marginal Probing (BOMP) index in a group of…

Effect of Fecal transplant harvested from Bariatric surgery subjects on Lipid and Glucose metabolism in subjects with metabolic syndrome;

To investigate whether single dosis of fecal therapy by infusion of allogeneic (post bariatric surgery donor feces in the bowel) or autologous (own feces) have differential effect on lipid-metabolism-mediated insulin resistance.

The effects of frontal transcranial direct current stimulation on the control of social emotional behavior

The aim is to specify the role of the vlPFC in the control of social emotional behavior. We will combine transcranial direct current stimulation (tDCS) and a modified version of the joystick affective AAT involving posturography (to assess postural…

Combining cognitive bias modification with rTMS: Evidence from a single session intervention in a dysphoric student population

The aim of this study is to test in a single session study in participants with subclinical depressive symptoms, whether adding ABM to rTMS treatment might maximize the beneficial effects on attentional bias, attentional control and emotional…

The effect of spinal anesthesia on pain perception and
sedation in healthy volunteers

(1) To assess the effect of deafferentation on pain processing in the brain by task-fMRI(2) To assess the effect of deafferentation on reaction time (sedation) by task-fMRI(3) To assess the effect of deafferentation on endogenous pain modulation

Multi-centre, randomized, investigator-blind, intra-individual active and vehicle-controlled study, comparing Metvix® Natural Daylight Photodynamic Therapy versus Metvix® conventional Photodynamic Therapy in subjects with actinic keratosis

Primary efficacy objective:To show the non-inferior efficacy of Metvix® Natural Day Light Photo Dynamic Therapy (NDL-PDT) versus Metvix® conventional Photo Dynamic Therapy (c-PDT) in Subjects with mild and moderate AKs at Week 12 in terms of percent…

Differential Susceptibility to Parenting: Gene-Environment Interactions in Children's Problem and Prosocial Behavior

The objective of this subexperiment is to test the hypotheses of emotional reactivity as underlying mechanism to GxE interactions in the behavior development of children. This hypotheses will be tested within an experiment in which we will look if…

In the heat of the moment - The effect of alcohol, sexual arousal and working memory capacity on reflective and impulsive cognitive processes involved in sexual risk behaviour..

In this research we will try to prove the validity of this dual systems model. We will use laboratory experiments to induce alcohol and sexual arousal and then measure their influence on working memory and sexual risk behaviour. After the laboratory…

Are the treatment outcomes of acute and chronic mallet fingers similar?

To assess whether there is a difference in the outcome in treatment of acute mallet fingers (exist <2 weeks) compared to chronic mallet fingers (exist > 4 weeks), using the same protocol of intensive follow-up by the '…

The effect of maltitol sweetened chewing gum on the oral microbiology.

What is the effect of the use of a maltitol sweetened chewing gum compared to a gum base and no gum in during a 28 days on the composition of the supragingival plaque microbiome in healthy non dental students *18 years old?

Telephone counseling to improve medication adherence of TIA patients

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A prospective, randomized, intra-patient, comparative, open, multi-centre study to evaluate the efficacy of a Single-Use Negative Pressure Wound Therapy (NPWT) System (PICO) on the prevention of postsurgical incision healing complications in patients undergoing reduction mammoplasty

Primary Objective:To assess the difference in healing complications up to and 21 days post-operatively between postsurgical incisions treated with PICO compared with standard of care Incision healing complications will include;* Skin necrosis*…