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Consequences of liver surgery for liver function and cell injury

1 Primary Objective To investigate the effects of 15* liver ischemia versus 30* liver ischemia on liver injury and liver function.To investigate the effect of liver manipulation during mobilisation for a right hemihepatectomy, that can be used as a…

The sensitivity of the pituitary thyrotrophs for ambient thyroid hormone levels.

The aim of this pilot study is;* To determine whether differences between individuals in the set-point of the HPT-axis can be determined by using this study-design,* To examine whether this study design is practicable and tolerated by the healthy…

effect of passive movement on severity of paratonia

1. Is passive movement therapy an effective intervention on the severity of paratonia in comparison with usual care without passive movement therapy?2. Is passive movement therapy an effective intervention for improvement of daily care?

Fear of Flying; a randomised controlled trial. Using subjective and psychophysiological measures to evaluate a cognitive based behavioral psychotherapy.

To evaluate the effectiveness of the cognitive based behavioral psychotherapy as given by the VALK Foundation by means of psychophysiological measures.

Effect of high-frequency chest wall oscillation and manual hyperinflation on the resolution of atelectasis in ventilated patients

Studies provide statistically significant evidence of the effectiveness of high-frequency chest wall oscillation administered via The Vest* System.St. Elisabeth Ziekenhuis Tilburg wants to demonstrate the effectiveness of HFCWO on ventilator-…

Randomised controlled clinical trial with GRAFTJACKET® , arthroscopic, soft-tissue interposition arthroplasty as a treatment of glenohumeral osteoarthritis.

The primary aim of the study is the prospective recording and follow-up of the clinical and radiographic data of patients who received soft tissue interpositional arthroplasty with Graft Jacket® as a treatment of painful glenohumeral osteoarthritis…

Is there a difference in result between PIP resection arthroplasty and PIP artrodesis in the treatment of rigid claw toes?

To indentify the surgical intervention with the best result in case of a rigid claw toe.

Bowel preparation for elective left-sided colonic surgery.

The objective of this study is to ascertain the best method of bowel preparation, prior to elective left-sided colonic surgery in terms of patient comfort and surgical efficacy. The occurrence of infections (wound, peritonitis) and anastomotic leaks…

A randomised controlled trial comparing the clinical and cost-effectiveness of the Avaulta anterior mesh and the standard anterior colporraphy for the primary surgical treatment of a cystocele stage >= 2

To compare the clinical and cost-effectiveness of an anterior colporraphy repair with a cystocele repair with the use of the non-absorbable synthetic Avaulta® mesh.

Modified treatment of port wine stains with the pulsed dye laser: a randomised controlled trial

The primary objective of this study is to assess the efficacyand safety of modifications of the laser treatment to increase the clearance of port wine stains.

Effect of aversive classical conditioning on sexual response in women with dyspareunia

The purpose of the present study is to clarify the assumed role of fear in women with superficial dyspareunia. The hypothesis will be tested that aversive conditioning in women with dyspareunia and control women will lead to diminished sexual…

Distal Pancreatectomy
A randomized controlled trial to compare two different surgical techniques

A successfully conducted trial will have a positive impact on the future handling of thepancreatic remnant in distal pancreatectomy. The reliable and comparable data generated in this trial may support an evidence-based choice of a surgical…

Scorpio PS vs Scorpio NRG PS total knee arthroplasty. Comparative investigation of function

This new developed knee prosthesis will be compared to the standard scorpio PS knee prosthesis. In this comparison it will be examined if the changes in design really do improve function and deminish pain. Allso patella tracking and patella tilting…

A Phase 3, Multicenter, Randomized Study Comparing CNTO 1275 and Etanercept for the Treatment of Moderate to Severe Plaque Psoriasis

The primary objectives of the study are to compare the efficacy of CNTO1275 to Etanercept and evaluate the safety of CNTO1275 and Etanercept.The secondary objective of this study is to evaluate the efficacy and safety of retreatment with CNTO1275.

Does short dipyridamole administration induce protection against ischemia-reperfusion injury?

The purpose of this project is to explore whether a short treatment with dipyridamole (2.5 days; i.e. 5 capsules) can reduce ischemia-reperfusion injury in the forearm.

Cost-effectiveness of an individually-tailored long-term worksite health promotion programme on physical activity and nutrition

The aim of the study is to evaluate the cost-effectiveness of a personal health portal on internet to promote physical activity and fruit and vegetables consumption among workers. The specific research questions are:1. Does the personal health…

Traditional Shoulder Rehabilitation Exercises versus Eccentric Exercises in Shoulder Patients with Subacromial Impingement Syndrome

The object of this study is to determine the effects of an eccentric muscle training for the supraspinatus muscle compared to the effects of a traditional rehabilitation program including strengthening exercises for the rotator-cuff and the scapular…

A randomised, single blinded, prospective, observational study of molecular biological effects of xenon inhalation used for early preconditioning in humans undergoing coronary artery bypass grafting

The aim of this study is to evaluate cardio-protective effects of xenon inhalation in humans and to identify enzymes contributing to cardio-protection influenced by xenon in patients scheduled for CABG surgery.

Does stress impair the inhibition of task-irrelevant emotional distracters during working memory?

Primary Objective: Using functional neuroimaging to assess differences in brain activation during WM at low and high load with emotional versus neutral distracters in participants with PTSD and in healthy participants with and without stress.…

The (cost-)effectiveness of mindfulness-based cognitive therapy and cognitive-behavioral treatment in adolescents and young adults with deliberate self-harm

To study the effects and costs of the total individual CBT package and one of the components of the total CBT treatment package (i.e. mindfulness training) in a group format compared to Treatment-as-Usual (TAU) on the short and long term.