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Spinal Morphine in Robotic Assisted Radical Prostatectomy

The primary goal is to increase the quality of recovery, as measured by the QoR-15-scale.Secundary goals are to decrease the use of systemic opiates, less bladderspasms and pain, reduce the side-effects op opiates, increase the patient-satisfaction…

Morphine intravenous vs. Acetaminophen intravenous in neonates and young infants undergoing major non-cardiac surgery.

The aim of this study is to test the hypothesis that intravenous acetaminophen will reduce morphine requirements in postoperative infants significantly (>30%).

Morphine versus piritramide (Dipidolor??) in postoperative analgesia. Time of onset of analgesia and incidence of postoperatieve nausea and vomiting after intravenous injecttion. A comparison.

The investigation of differences between morphine and piritramide concerning the incidence of postoperative nausea and vomiting and the time of onset of adequate analgesia.

Randomized clinical trial of the optimization of procedural pain control in ICU patients

The primary objective of this study is to determine the influence of morphine dosage (2.5 mg vs 7.5 mg) on the percentage of patients with a rated NRS of >= 4 during an painful and unavoidable intervention. The secondary objectives are to…

Morphine intravenous vs. paracetamol intravenous after cardiac surgery in neonates and infants.

The aim of the study is to test the hypothesis that intermittent intravenous paracetamol administration in children after cardiac surgery will result in a reduction of at least 30% of the cumulative morphine requirement.

Randomized, double-blind, placebo controlled, multi-centre superiority phase II study to evaluate the safety, pharmacokinetic, efficacy of gabapentin liquid formulation as add-on to morphine in children from 3 months to less than 18 years of age experiencing severe chronic neuropathic or mixed pain.

The primary objective of this study is to assess the efficacy of gabapentin as add-on to morphine for the treatment of severe chronic neuropathic or mixed pain in children from 3 months to less than 18 years of age. Secondary objectives 1. To assess…

A Randomized, double-blind Crossover Trial to Investigate the Effects of Oliceridine and Morphine on Ventilatory Drive and Pain Relief in Healthy Elderly Subjects * a population pharmacokinetic/pharmacodynamic modeling study

Primary: - To evaluate the ventilatory and antinociceptive effects of intravenous doses of oliceridine and morphine by population PK/PD modeling in an older population across a range of body weights including subjects meeting the criteria for being…

Spinal morphine in patients with hip fractures to reduce delirium

The main objective is to decrease the incidence of delirium in patients receiving surgical treatment of a proximal femur fracture with spinal anesthesia.

A proof of concept randomized, double-blind, parallel group, controlled dose-finding and safety study of STR-324 in post-operative pain

The main objective of this dose-finding study is to evaluate the analgesic effect of STR-324 (maximum 4 increasing doses and maximum 2-hours infusion) on post-operative pain, measured by change of pain intensity assessed on a Numerical Rating Scale…