18 results
The primary objective is to confirm the hypothesis that Maraviroc stimulates immune recovery; the ssecondary objective is to explore, by virologic and immunologic investigations, the underlying mechanisms of this hypothesis.
1 : Will the intake of a liquid meal lead to insulin-induced microvascular dilatation in healthy subjects? 2: Does meal composition (high fat meal vs. high carb meal) play a role in the occurence of insulin-induced microvascular dilatation in…
To assess clinical parameters and biomarkers in blood and urine in predicting bacteremia, need for hospital admission, clinical and bacteriologic cure and mortality in patients with fUTI.To determine whether a 7-day duration of antibiotic treatment…
The goals of the proposed study are: (1) to further elucidate the relations between impulse control, motivational strength of drug cues, and brain activation patterns (using fMRI); (2) to examine the relative strength by which these processes are…
Main study:1. Does blockade of the angiotensin II AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients.2. Does blockade of the angiotensin II AT1-receptor impair the insulin-induced mi-crovascular effects in…
Study ObjectiveTo determine whether alprazolam, a registered anxiolytic non-selective benzodiazepine, can reduce the autonomic temperature increase induced with social stress in healthy men. Secondary objectives are to determine whether alprazolam…
The project is focused on induction of immune tolerance in allergy by prebiotics. The pathophysiology of immune modulation will be investigated and searched for potential biomarkers for immune modulation.
We would like to modulate the serotonin system with acute tryptophan depletion (ATD) and 5-hydroxytryptophan (5-HTP). ATD is based on ingestion of an amino acid drink devoid of the precursor of serotonin and hence caused a decreased serotonin level…
Assess whether APL180 can improve endothelial function in patients with Familial hypercholesterolemia
To study the possible beneficial effect of simvastatin on accumulation of triglycerides in the myocardium of patients with DM2 and the effect on vessel wall thickness using magnetic resonance imaging and spectroscopy
To determine the incidence and grade of venous emboli and/or paradoxical gas emboli during hysteroscopy surgery using TOE. In addition, a comparison will be made using either bipolar or monopolar diathermia. Knowing the incidence and severity of…
To determine the efficacy of oral supplementation with vitamin B12 and folic acid in the prevention of fractures.
We hypothesize that local AMPs expression in the airways of patients with asthma is decreased as a result of allergic inflammation. Furthermore, we hypothesize that local AMP expression can partly be restored by vitamin D substitution therapy. We…
Primary Objective: What is the frequency of positive patch test reactions to the 26 declarable fragrance allergens in fragrance mix I and/or II positive participants?Secondary Objectives: Do Weleda cosmetic products containing essential oils,…
· To determine therapeutic efficacy of Tracleer in patients with active Behcet disease. Furthermore:· To study cytokine and immunological patterns and ET-1levels in those patients.
Project 1: To investigate the neuroanatoimical correlates of attentional processing bias in nicotine addicts, using fMRI.Project 2: To examine whether attentional biases are dependent on dopaminergic transmission in the mesolimbic system using…
The aim of this research is to determine the effect of glucose in the small intestine on the secretion of hormones, appetite related feelings and food intake, and whether these effects differ between time of day (morning vs evening) and segment of…
It is not known whether recurrent wheeze in preterm children is caused by RSV infection (serial hypothesis) or that RSV infection is the first indication of chronic airway morbidity that would develop anyway (parallel hypothesis). This study aims to…