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A randomized, double-blind, placebo controlled, parallel group, multi-centre, 2-week treatment study to evaluate the safety and efficacy of fluticasone furoate nasal spray (FFNS) 110 mcg, administered either once daily or twice daily, compared with placebo, as effective monotherapy in the treatment of uncomplicated acute rhinosinusitis (ARS) in adult and adolescent subjects 12 years of age and older.

The objective of this study is to evaluate the safety and efficacy of two doses of FFNS (110 mcg once daily and 110 mcg twice daily) compared to placebo as monotherapy in the treatment of adult and adolescent subjects 12 years of age and older with…

A randomized, double-blind, placebo controlled, single-dose study to assess the initial efficacy of canakinumab (ACZ885) with respect to the adapted ACR Pediatric 30 criteria in patients with Systemic Juvenile Idiopathic Arthritis (SJIA) and active systemic manifestations

The primary objective of this study is:To demonstrate that the percentage of patients who meet the adapted ACR Pediatric 30 criteria at Day 15 is higher with canakinumab compared to placebo.Secondary objectives of this study are:* To evaluate the…

A randomized, double-blind, placebo controlled, withdrawal study of flare prevention of canakinumab (ACZ885) in patients with Systemic Juvenile Idiopathic Arthritis (SJIA) and active systemic manifestations

The primary objectives of this study are:Part II: to demonstrate that the time to flare in Part II is higher with canakinumab than with placebo.Part I: to assess if canakinumab allows tapering of steroids as per protocol in at least 25% of…

A Worldwide, Randomized, Double Blind, Placebo-Controlled, Parallel Group Clinical Trial to Evaluate the Safety and Efficacy of Rizatriptan for the Acute Treatment of Migraine in Children and Adolescents

The objective of this study is to test the safety of the research study drug, MK-0462 (rizatriptan) and to test the ability of study drug to relieve or reduce migraine for the study population.

A Phase 3, Randomized, Double-Blind, Multinational, Placebo-Controlled Study to Evaluate Efficacy and Safety of Teplizumab (MGA031), a Humanized, FcR Non-Binding, Anti-CD3 Monoclonal Antibody, in Children and Adults with Recent-Onset Type 1 Diabetes Mellitus

Primary: The primary objective of this study is to assess relative to placebo, the efficacyof teplizumab when administered according to 3 different teplizumab dosing regimens in subjects with recent-onset T1DM (within 12 weeks of presentation of…

Inspiratory muscle training prior to peripheral muscle training in patients adolescents with Cystic Fibrosis.

1. Is a home-based peripheral muscle training program (5BX) more effective in (a) increasing peak work rate and (b) patients* preferred occupational performance in patients with CF who are preconditioned by IMT?2. Which variables are indicators of…

PRISMA: Pediatric oncologic Research on Improving Speed, Memory and Attention
THE EFFICACY OF NEUROFEEDBACK TO IMPROVE ATTENTION AND MEMORY IN CHILDHOOD BRAIN TUMOUR SURVIVORS: A DOUBLE BLIND, RANDOMIZED, PLACEBO CONTROLLED TRIAL

The aim of this study is to investigate the efficacy of neurofeedback to improve attention and memory in children that have been treated for a brain tumour. If the neurofeedback proves to be effective, we will strive to implement this training for…

The protective effect of a nasal steroid (Fluticasone furoate) on exercise induced airway obstruction in cold air.

Analyze the protective effect of intranasal corticosteroids against exercise induced upper and lower airway obstruction

The protective effect of a nasal corticosteroid (Avamys) on exercise induced airway obstruction in cold air.

Analyze the protective effect of fluticasone furoate, through reduction of allergic rhinitis, against exercise induced airway obstruction.

CNS Drug Effect Profiling in Children: an Educational Class Experiment using Caffeine as a Model.

- To educate adolescents on clinical drug studies by involving them as project team members and participants in an intervention trial of negligible risk and minimal burden; - To investigate the CNS effects of caffeine on neurocognitive and…

Long Term Administration of Inhaled Mannitol in Cystic Fibrosis - A Safety and Efficacy Study

The purpose of this study is to examine the efficacy and safety of 26 weeks treatment with inhaled mannitol in subjects with cystic fibrosis. Previous studies with inhaled mannitol have demonstrated improvements in lung function, mucociliary…

The use of fluoride rinse for caries prevention during the orthodontic treatment with fixed appliances

Our aim is to find methods to effectively reduce the caries incidence during orthodontic treatment with fixed appliances. A secondary aim is to study the effect of fixed orthodontic appliances on the plaque ecology in relation to caries development.

Effect of dietary suppletion with genestein in patients with the MPS III

The objective of the study is to establish the effect of genestein in patients with MPS III on urinary and serum GAGs levels, hair morphology, GAG accumulation in skinbiopsy, cognitive functions and behavior (Piotrowska et al, 2008).MPS III is a…

A Phase 2/3, double-blind, randomized, placebo-controlled, multi-center study to evaluate the efficacy and safety of OxabactTM to reduce urinary oxalate in subjects with Primary Hyperoxaluria.

Primary Objective:To evaluate the efficacy of OxabactTM to reduce urinary oxalate levels (molar oxalate to creatinine ratio) from Baseline to Week 24 in subjects with Primary Hyperoxaluria (PH).Secondary Objectives- To evaluate the safety of…

Second IVIg Dose in GBS patients with poor prognosis (SID-GBS trial)

To determine whether a second IVIg course in GBS patients with a poor prognosis improves functional outcome after 4 weeks.