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Glucose response to a formula for patients at risk of hypoglycaemia

The aim of the present study is to assess whether the postprandial glucose response of the new test products is superior to the postprandial glucose response of an original treatment option.

Effect of low dose galacto-oligosaccharides (GOS) on faecal gut microbiota in adult women

The primary objective is to investigate the effect of a 3 week intervention with either 1.,3 gram or 2 gram of GOS on the abundance of the genus Bifidobacterium in faecal samples in healthy women of 40 - 70 years old. The secondary objective is to…

A Partially Double-Blinded Phase 1 Study to Assess the Safety, Tolerability and Pharmacokinetics of AST-004 as a Short Loading Intravenous infusion Followed by AST-004 as a Continuous Infusion in Healthy Adult Subjects.

Primary objective:• To evaluate the safety and tolerability profile of single intravenous doses of AST-004 given as a short loading intravenous infusion followed by a 6-hour continuous intravenous (IV) infusion in healthy adult subjects.Secondary…

Dairy and Plant amino acid uptake - An explorative study

The primary objective is to estimate differences in postprandial plasma total essential amino acids (TEAA) profiles after protein consumption, determined by appearance (profiling, iAUC and peak Cmax), between pea, faba, casein, and whey in blood of…

A Phase 1b/2a, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate Nebulized Bacteriophage Treatment in Outpatient Adult Cystic Fibrosis (CF) Subjects with Chronic Pseudomonas aeruginosa (PsA) Pulmonary Infection

Primary Objective:To evaluate the safety and tolerability of nebulized BX004-A in CF subjects with chronic PsA pulmonary infection.Exploratory Objective:To evaluate the effect of BX004-A on sputum PsA burden, lung function, frequency of APEs, and…

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study with an Open-Label Extension to Evaluate the Efficacy and Safety of Oral Rilzabrutinib (PRN1008) in Adults and Adolescents with Persistent or Chronic Immune Thrombocytopenia (ITP)

Primary Efficacy Objective (Blinded Treatment Period)• To demonstrate the efficacy of rilzabrutinib versus placebo in participants with refractory/relapsed ITP, based on the durability of platelet response during the last12 weeks of the 24-week…

Safety and Viability of an E. coli Nissle Colibactin Knockout in Healthy Volunteers: A Randomised Controlled Safety Study

Assess the safety and tolerability of the EcNΔClbP strain relative to the EcN wildtype strain following a 1-week daily administration, through questionnaires, medical examination and measurement of inflammatory markers.

Evaluation of GeranylGeranylAcetone in heart failure with preserved ejection fraction

Primary objectivesTo study whether Geranyl-Geranyl Acetone (GGA) reduces left ventricular (LV) diastolic dysfunction in patients with HFpEF compared to placebo (and to assess/confirm its effectiveness and safety in patients with HFpEF)Secondary…

Validation of the Virtual Reality PainCart using diazepam: a randomized single center, double-blind, placebo-controlled, cross-over study investigating the affective component of pain

• To assess the change in electrical pain perception induced by virtual reality.• To assess the effect of diazepam on electrical pain perception. • To assess the relationship between the electrical pain perception and personality characteristics.

The impact of canola protein processing on postprandial plasma amino acid responses in vivo in young females

The goal of this study is to investigate the most optimal way of canola protein processing on blood plasma amino acid responses in young females.