61 results
To compare the rapidity of onset and the extent of oxidative stress lowering of atorvastatin with that of an (in terms of LDL lowering) equipotent dosage of simvastatin.
1) To examine the effect of 3 weeks of 18*g tiotropium bromide once daily on the degree of bronchodilation following deep inspiration at a given level of bronchoconstriction.2) To examine the effect of 3 weeks of 18*g tiotropium bromide once daily…
To provide an answer to the following questions: 1. In patients with AD, does treatment with a ChEI improve cerebral hemodynamics? 2. Is there less progression of cerebrovascular lesions on follow-up of AD patients receiving ChEI*s? 3. Does this…
The objective of this project is to study the role of dopaminergic mechanisms in apathy, mood and HDD in patients with PD. What is the involvement of the dopaminergic neurotransmitter system in motivation and reward processes in PD and the clinical…
With this study we want to identify the common aetiology and neurobiology of EFD, by employing pharmacological and genetic imaging in three neuropsychiatric disorders. We want to identify an underlying functional and structural model for EFD,…
The main objective of this project is to study the relationship between dopaminergic mechanisms and apathy in dementia. The related question, both theoretically and of direct relevance for daily practice, is whether patients with dementia are…
To study the effect atorvastatin 80mg on (central) sympathetic activity in hypertension patients.
The project is focused on induction of immune tolerance in allergy by prebiotics. The pathophysiology of immune modulation will be investigated and searched for potential biomarkers for immune modulation.
Using the model of lipid-induced insulin resistance we will study the hypothesis that pre-treatment with salsalate (salicylsalicylic acid) blunts the development of lipid-induced insulin resistant in an I*B/NF*B dependent manner in healthy human…
A. What are possible causes of MP and what patients variable are asssociated with MP. What is the natural course and prognosis of MP. What is the influence of MP on the quality of life.B. What is the diagnostic value of SSEP en nerve conduction…
The primary aim of this study will be to determine the effect of rosiglitazone on intima media thickness and calcification in patients with stage 4 and 5 CKD. The secondary end points are the effects on pulse wave velocity, blood pressure, the lipid…
In previous studies is found that the sequence of processes leading to excessive scar formation starts during the operation. Abnormal epidermal-dermal interactions and excessive immune reactions seem to play an important role.On theoretical base an…
Main study:1. Does blockade of the angiotensin II AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients.2. Does blockade of the angiotensin II AT1-receptor impair the insulin-induced mi-crovascular effects in…
To determine the incidence and grade of venous emboli and/or paradoxical gas emboli during hysteroscopy surgery using TOE. In addition, a comparison will be made using either bipolar or monopolar diathermia. Knowing the incidence and severity of…
To determine the efficacy of oral supplementation with vitamin B12 and folic acid in the prevention of fractures.
Study ObjectiveTo determine whether alprazolam, a registered anxiolytic non-selective benzodiazepine, can reduce the autonomic temperature increase induced with social stress in healthy men. Secondary objectives are to determine whether alprazolam…
· To determine therapeutic efficacy of Tracleer in patients with active Behcet disease. Furthermore:· To study cytokine and immunological patterns and ET-1levels in those patients.
Primary Objective: To investigate the effect of supplementation of a single high dose of vitamin D (400.000 IU) on 1. the percentage of neutrophils in induced sputum, in non-atopic asthmatic patients with neutrophilic airway inflammation (…
We hypothesize that local AMPs expression in the airways of patients with asthma is decreased as a result of allergic inflammation. Furthermore, we hypothesize that local AMP expression can partly be restored by vitamin D substitution therapy. We…
The primary objective is to confirm the hypothesis that Maraviroc stimulates immune recovery; the ssecondary objective is to explore, by virologic and immunologic investigations, the underlying mechanisms of this hypothesis.