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Periarticular penetration of cefazolin and clindamycin in second stage revision arthroplasty of the hip.

The primary objective is to determine the penetration of cefazolin and clindamycin in synovial fluid and bone tissue related to the serum concentration in subjects undergoing reimplantation of the hip.

Preoperative sodium glucose cotransporter 2 inhibitors for prevention of postoperative acute kidney injury in cardiac surgery patients - a randomized, placebo-controlled, multi-centre, phase IV clinical trial

This study has been transitioned to CTIS with ID 2024-515260-31-00 check the CTIS register for the current data. To investigate the potential of preoperative initiation and perioperative continuation until day 2 after surgery of the SGLT2 inhibitor…

Clinical investigation of the Qmedics EXIST NiTi Stent type Flex & Pull in adults with Peripheral Artery Disease (PAD) (of the Q-medics NiTi Stent Family.

The objective of the HORIZON trial is to demonstrate and provide long-term clinical data on safety and performance of the Qmedics EXIST NiTi Stent System type FLEX & PULL for treating de novo or re-stenotic symptomatic atherosclerotic…

An intervention to address feelings of shame and guilt related to survival based behavior after (sexual) assault.

The present study proposes to investigate the On(t)schuldig intervention. The main research question: Do adolescents report less trauma-related feelings of shame and guilt after following the intervention On(t)schuldig?

Goal directed fluid removal with furosemide in intensive care patients with fluid overload - A randomised, blinded, placebo-controlled trial

This study has been transitioned to CTIS with ID 2024-512186-14-00 check the CTIS register for the current data. To assess benefits and harms of goal directed fluid removal with furosemide versus placebo on patient-important outcome measures in…

DEnosumab for the treatment of FIbrous Dysplasia/McCune-Albright Syndrome in adults (DeFiD): a randomized double-blind placebo-controlled trial

This study has been transitioned to CTIS with ID 2024-511090-30-00 check the CTIS register for the current data. To investigate whether 3 monthly Dmab will improve the clinical, radiological and biochemical manifestations of FD bone lesions.

BCG-induced epigenetic modifications in the NEXT generation

To study the possible epigenetic modifications in sperm cells after BCG vaccination

Population pharmacokinetics of mycophenolate mofetil in autoimmune diseases

Primary objective: to investigate MPA exposure in a variety of autoimmune diseases in stable treated patients. Secondary objective: to develop predictive exposure models and evaluate the influence of population covariables on pharmacokinetics .The…

Minimally Invasive versus Open Lumbar Interbody Fusion Trial (MIOLIFT): a randomized controlled trial for surgical treatment of lumbar spondylolisthesis and foraminal stenosis

Currently, available literature on costs and clinical effectiveness of MITLIF compared to OTLIF for patients with lumbar spondylolisthesis and degenerative foraminal stenosis is not sufficient. With a steep increase in the number of instrumented…

A Prospective, Multicenter Study of the Indigo* Aspiration System Seeking to Evaluate the Long-Term Safety and Outcomes of Treating Pulmonary Embolism

The objective of this study is to evaluate real world long-term functional outcomes, safety and performance of the Indigo Aspiration System for the treatment of pulmonary embolism (PE)

Study on PhArmacokiNetics of first liNe Antiretrovirals in healthy Breastfeeding volunteers
(PANNA-B PK)

This study has been transitioned to CTIS with ID 2023-510232-36-00 check the CTIS register for the current data. to determine the concentration of currently often used ARV (doravirine, raltegravir, bictegravir, tenofovir alafenamide, emtricitabine)…

POPular GUILTY pilot: Genotype-guided clopidogrel monotherapy

This study has been transitioned to CTIS with ID 2024-518464-12-00 check the CTIS register for the current data. The primary efficacy endpoint is to assess ischemic risk of genotype-guided clopidogrel monotherapy during the first 6 months following…

Use of mechaNical left ventricuLar unlOADing in Complex Higher-risk Indicated Procedures

The primary objective of the UNLOAD-CHIP is to investigate the combined clinical endpoint (as described in primary and secundary endpoints).

The effect of low-dose rhythmic 17-β-estradiol administration on bone turnover in postmenopausal women

To investigate the effect of low-dose rhythmic transdermal 17-β-estradiol on serum P1NP (marker of bone formation) and CTX (marker for bone resorption), versus continuous low-dose and standard-dose continuous transdermal 17-β-estradiol…

Determination of tocilizumab trough levels during dose tapering in patients with rheumatoid arthritis (OPTIRA study)

Primary objectives: - To determine in which percentage of the included patients tocilizumab is successfully tapered or discontinued after 12 months (successful = lower dose than at baseline with a DAS28-ESR <=3.2). - To identify the serum…

Multiple Sclerosis treatment with Autologous Hematopoietic Stem Cell Transplantation (MS-ACT): A long-term prospective observational study in the Netherlands

To perform long-term pre-specified follow-up of patients undergoing aHSCT for refractory RRMS.

Prospective non-randomised post-market study collecting clinical data on safety and effectiveness of the remed*®-System

This study aims to assess the safety and efficacy of the remed*® system in adult patients with moderate to severe central sleep apnea in real life.

DiEtary Sodium Intake effects on ertugliflozin-induced changes in GFR, reNal oxygenation and systemic hemodynamics: the DESIGN study, a randomized, placebo-controlled, cross-over study with ertugliflozin in people with type 2 diabetes

This study has been transitioned to CTIS with ID 2023-510257-42-01 check the CTIS register for the current data. Sodium-glucose cotransporter 2 (SGLT2) inhibitors lead to a lowering of blood pressure and confer cardiovascular and renal protection in…

Effect of a bundle of non-pharmacological interventions on the stress response to surgery

To assess the effect of a bundle of non-pharmacological interventions implemented in the post-anesthesia care unit on the total serum cortisol levels after intermediate and major surgery.

Body Weight Adjusted Clopidogrel treatment in patients with CORonary artery Disease (BW-ACCORD)

This study has been transitioned to CTIS with ID 2024-518890-33-00 check the CTIS register for the current data. To determine if clopidogrel treatment can be optimized in patients with a low or high BW/BMI compared to patients with a normal BW by…