1768 results
To contribute to building a sound scientific basis for the regulatory EU institution to set-up occupational exposure limits and related biological limit values, as well as reference values for the general population and to study the impact of the…
The aim of the study is to investigate the effect of magnetic resonance (MR) based online adaptive radiotherapy (RT) for treatment of low to intermediate risk localized prostate carcinoma (PCa) on the radiotherapy dose on the prostate and organs at…
1. To validate the existing guidelines with prospective and retrospective data from this cohort by performing an upper endoscopy at baseline, one year after inclusion and subsequently every three years thereafter in order to assess the risk of…
The aim of this study is to investigate whether a smartphone app can increase physical activity in PDpatients for a long period of time (one year). The secondary aim is to test the potential effects of an increase in physical activity on physical…
The primary objective of the study is how patients with therapy resistant anxiety or depression evaluate a well-being intervention *living well with a chronic mental health disorder* and if they experience an increase in personal recovery and mental…
The goal of the study is 1) showing that EA, CA and perceived control are not stable but of dynamic nature and interact in predicting social anxiety symptom severity, 2) identifying possible mechanisms of change of CBT (the exact working of which is…
To assess cognitive impairment in participants with highly-active RMS, having participated in the CLARIFY MS trial, at 4 years afterinitial dose of cladribine tabletsTo assess health related quality of life (HRQoL) in participants with highly-…
This study has been transitioned to CTIS with ID 2024-513412-10-00 check the CTIS register for the current data. Phase 1: • To determine the MTD/RP2D regimen of brigatinib monotherapy when administered in pediatric and AYA patients with ALK+ ALCL or…
Part 1: Dose-Escalation Stage (not in The Netherlands)Primary objective:* Safety and tolerability of HBM4003Secondary objectives:* Preliminary anti-tumor activities of HBM4003 in advanced solid tumors* Pharmacokinetics (PK) of HBM4003Other…
In this study we will investigate how quickly and to what extent the new compound JNJ-67856633 is absorbed, transported, and eliminated from the body. JNJ-67856633 is radioactively labelled with carbon-14 (14C).We also investigate how safe JNJ-…
The primary aim of the study is to assess the prevalence of MDRO carriage in patients undergoing ERCPs. This will be performed in four different countries with expected significantly different prevalence rates of MDRO carriage, namely: India, United…
The aim of this study is to investigate the extent to which changes are observed in a physically active man, aged around 85 years in 1) PIFMs* size, 2) dynamic balance and 3) foot function during gait after participating in a PIFM strengthening…
The main objective of this study is to validate the accuracy of the device to monitor the physical activity of a subject by comparing the measured values to the golden standard (video recording).
In this study we will investigate how safe the new compound leniolisib is and how well it is tolerated by healthy male participants.We also investigate how quickly and to what extent leniolisib is absorbed, transported, and eliminated from the body…
In this study we will investigate biomarkers in blood after exposure to heparin in the fasted state or after a high-fat meal. Biomarkers are proteins present in the blood. The biomarkers investigated in this study are proteins that are involved in…
Primary Objective: The primary objective of this study is to investigate the prevalence EPI in the advanced HF population Secondary Objectives: • To determine the association between exocrine pancreatic function and markers of HF• To determine the…
Part 1:Primary objective:• To estimate the relative bioavailability of two THB001 formulations in healthy adults.Secondary objectives:• To determine the single-dose pharmacokinetics (PK) of THB001•HCl salt and THB001 free base formulations in…
Energy- and nutritional requirements in professional female soccer players: The ProSoccer 2.0 Study.
ln the current study we aim to assess the energy requirements and physical activity patterns in professional female soccer players along with their nutritional intake patterns. As such, this study will provide valuable information to optimize the…
The primary aim of this study is to examine the feasibility, usability, and acceptability of the educational care pathway for both patients and healthcare professionals. The secondary aim is to investigate the preliminary effects on patients*…
To characterize the immunological read out, e.g. the immune cell compartments, and antibodies of patients with autoimmune bullous diseases during rituximab treatment and during relapses.