840 results
This study aims to examine the effect of furosemide on renal PBUT excretion and PBUT plasma levels in patients with CKD.
The main objective is to quantify neuroinflammation using [11C]SMW139 PET-scans in subjects along the AD continuum and age/sex-matched cognitively unimpaired subjects.
The study has two objectives:1. To relate pulmonary fibroblast activity in non-resolving ARDS patients, measured by FAPI-PET/CT, to the 28 days mortality, ventilator-free days of 28 days (VFD-28) and ICU length of stay. 2. To study the relationship…
The primary objective of this study is to evaluate the coronary plaque burden and plaque characteristics in young T1DM patients as compared with non-diabetic healthy controls, using coronary computed tomography angiography (CCTA). The secondary…
Primary:Determine baseline and changes over time in cardiac structure and function in BAG3 associated DCM.Secondary:Assess the progression of prognostic disease biochemical biomarkers in BAG3 associated DCM.
This study has been transitioned to CTIS with ID 2024-515885-15-00 check the CTIS register for the current data. Main objectives:• To evaluate whole body distribution of 89Zr-Df-crefmirlimab in cancer patients prior to and during treatment with an…
1. To examine whether there is an increase in (nigro)striatal dopaminergic functioning in individuals of West-African descent relative to those of Dutch descent (assessed in older participants with DAT SPECT and with NM-MRI in the entire sample). (…
This study has been transitioned to CTIS with ID 2024-514266-39-00 check the CTIS register for the current data. Phase 1 Primary Objective(s):-to evaluate the overall safety and tolerability of NVL-655-to determine the RP2D and, if applicable, the…
In this project we aim to develop a safe and effective technique for ADC/FET-guided resection of IDH-wildtype glioblastoma and grade IV IDH-mutant astrocytoma. The safety concerns neurological deficits and time to start of adjuvant therapy, while…
To establish the performance of the TouchCare Nano 14 CGM system among persons with DM.
This study has been transitioned to CTIS with ID 2024-515417-17-00 check the CTIS register for the current data. The main objective of this trial is to investigate glucagon receptor occupancy of BI 456906 in the liver with PET imaging using the…
This study has been transitioned to CTIS with ID 2024-518838-82-00 check the CTIS register for the current data. To evaluate if a combination of FAPI-PET/CT and FDG-PET/CT scan is able to detect active fibroblast tissue and inflammation in patients…
Primary safety objective: The primary safety objective of the study is to assess the safety of the Apreo Endobronchial System for treatment of severe emphysema.
This study has been transitioned to CTIS with ID 2024-517805-10-01 check the CTIS register for the current data. We aim to investigate whether sodium oxybate can be used as a novel treatment in psychiatric patients with catatonia. Our primary…
The purpose of the study is to provide comparative analysis of breast imaging modalities of BCT (nu:view) compared to MRI.
This study has been transitioned to CTIS with ID 2024-518065-10-00 check the CTIS register for the current data. The aim of the study is to demonstrate that HAI P chemotherapy is an effective treatment for unresectable intrahepatic…
The main objective of this proposal is to establish ex-vivo models of bronchial epithelial cells from children. Use of (1) epithelial organoid cultures derived from bronchial or nasal epithelial cells; and of (2) bronchial brushings; (3) nasal…
To determine the diagnostic performance (sensitivity, specificity, and area under the ROC curve) of the current eye-movement based perimetry techniques, SONDA and BulbiCAM, as potential screening instruments for glaucomatous VF defects in ophthalmic…
This project has the following objectives: 1) to determine the effect of vertical, horizontal and mediolateral supportive forces of the RYSEN on gait parameters and muscle activity in able bodied individuals and patients; 2) determine the…
Determine the safety (oncologica! outcome and toxicity) of an comprehensive treatment combining recent advances in the treatmentof high risk prostate cancer.