1440 results
Focusing on disease-modifying rather than etiologic mechanisms may accelerate the development of novel therapies and complement current research initiatives on causative mechanisms and curative therapies.
COMT and/or PRODH polymorphisms are debt to cognitive deterioration in velocardiofacial syndrome.
the aim of this study is to compare two strategies that present a large contrast in the stimulation dosage, i.e. a high dosage of stimulation versus a low dosage of stimulation. Our study is designed to objectively compare the ongoing pregnancy rate…
Addittional training of teachers will result in greater effect-sizes for a school-based child intervention program for childhood behavior problems. Assessment of stepped-care child, teacher and parent intervention.
Submucous fibroids are known to be related to heavy menstrual bleeding (HMB), dysmenorrhea and fertility problems. Transcervical resection of fibroids (TCRM) is a widely implemented treatment for submucous fibroids, to be precise FIGO PALM-COEIN…
Obesity is a growing world wide problem. In The Netherlands, about 10% of all men and women have a BMI of 30 kg/m2 or more. Obesity is a chronic, uncurable metabolic disorder, which is characterised by excessive fatstorage at unfavorable places.…
Kidney transplantation is the only treatment offering long-term benefit to patients with chronic kidney failure. Urological complications after kidney transplantation, such as urinary leakage and ureteral strictures, are associated with significant…
The level of AGEs can predict response to intravitreal anti-VEGF therapy in DME
The primary research questions are: 1. To what extent does a 4 week ReHab-TOAT regime lead to improvement of arm function in chronic stroke patients with either a severely or moderately affected arm-hand? 2. To what extent is any improvement of arm…
1. The intervention 'Happiness Route' is effective in promoting positive mental health in comparison to a control condition that consists of optimized care-as-usual; 2. In comparison to the control condition, the intervention '…
It is expected that coblation treatment has an effect on knee cartilage quality in patients with meniscal lesions and cartilage loosening of the knee
Our primary outcome is change in suicide ideation in patients. We hypothesise that, as a result of the improved skills and confidence of healthcare professionals in the experimental condition due to the intervention, suicidal patients are better…
The purpose of this research is to acquire a better understanding of the pain experience and the recovery of children between 1.5 and 5 years old who underwent a tonsillectomy/adenotonsillectomy. Primary research question: What is the influence of…
Part A: In clinical practice the use of simplified quantitative methods and procedures can be fully validated against complex quantitative kinetic measures. Part B: Test-retest repetability of different SUV measures, metabolic and anatomic volume…
We expect that patient who receive care according to the protocol about 24/7 availability of specialized palliative care in the home situation, during the year of the study will die more often at home than patients in the years before start of the…
1. Alcohol marketing influences youth drinking 2. The following factors moderate of mediate the relationship between marketing & drinking: a. Personal relevance of advertisements, b. Sociability, parental guidance in understanding TV and…
End stage kidney disease (ESKD) ranks among the most severe chronic non-communicable diseases with an unmet medical need, given the high (between 10% and 20%) and stable annual mortality rates in ESKD patients treated with dialysis. Kidney…
Donor-specific antibodies form a significant barrier in transplantation of highly pre-sensitized dialysis patients. Increased waiting time is associated with increased morbidity and mortality among these patients. Thus, there is a need to further…
To assess whether temporary discontinuation of antihypertensive therapy in mildly cognitively impaired older patients on antihypertensive treatment improves cognitive and psychological functioning.
Providing feedback on practice patterns and practice variation will reduce variation between hospitals