341 results
The aim of this study is to investigate efficacy of a manuka honey lavage in the treatment of three distinct disorders; persistent clostridium difficile infection (CD), budesonide dependent microscopic colitis (MC), and therapy refractory irritable…
To evaluate the effectiveness of a multidisciplinary outpatient group-based nutrition and lifestyle intervention program *Reverse diabetes type 2* executed by Voeding Leeft on self-reported haemoglobin A1c (Hb1Ac) as measure of glucose regulation…
The purpose of the study is to investigate the use of secukinumab (AIN457) treat ment in children from 2 to18 years of age with either active Enthesitis -Related Arthritis (ERA) or Juvenile Psoriatic Arthritis (JPsA) subtypes of Juvenile Idiopathic…
The primary aim of this first line 177Lu-PSMA RLT study is to evaluate the clinical efficacy in castration resistant metastatic prostate cancer. Secondary aims are to assess the progression free survival (radiographic, clinical or PSA progression…
Goals is Doel to study whether this new distractor is indeed more userfriendly.
The primary objective of the study is to evaluate neurocognitive function with use of Praluent after 96 weeks of treatment versus placebo.
1. The primary objective of this phase I/II clinical trial is to evaluate the safety and toxicity of ACT plus nivolumab according to CTCAE 4.0 criteria. Toxicity grade 3 or less and SAE related to treatment but that does not result in treatment…
The main objective is to investigate the effectiveness of parenting programs addressing family functioning and PTSD within the Dutch veteran population. A secundary objective is to unravel and identify the role of emotion regulation and…
To demonstrate that treatment with avelumab in combination with standard of care (SOC) CRT is superior to SOC CRT alone in prolonging progression-free survival (PFS) in front-line patients with high-risk (as defined in Inclusion Criterion 2),…
To set up a cohort of patients undergoing radiological interventions, which will serve as a platform for randomized evaluation of different pain and anxiety management strategies in order to improve on routine care by searching for a more effective…
This study investigates the safety and tolerability of deferoxamine use in patients with aneurysma subarachnoid hemorrhage.
Objectives: 1. The primary objective is to evaluate the safety and immune modulation of TIL plus IFN* in epithelial ovarian cancer (EOC) patients and to determine the optimal dose of IFN* that can be given in combination with chemotherapy.2.…
The primary objective of the study is to descriptively characterize the single-dose and steadystatePharmacokinetics (PK) of diacerein (if quantifiable) and its active metabolite, rhein, after topical application of CCP-020 (diacerein 1% ointment)…
To improve BP control and health related quality of life by offering a nurse-led patient-centred supportive intervention to people with T2DM who are objectively non-adherent to their antihypertensive medication and/or life style behaviour…
The purpose of the clinical study is to demonstrate sustainable pain control and positive psychosocial and functional effects using a neuromodulation system using Burst stimulation
To quantify clinical and histological changes of the skin in promoting early wound healing when SVF + PRP injectable is used as treatment in comparison to SVF and PRP alone.
Objective: The primary objective of this study is to evaluate the pharmacokinetics of midazolam in elderly patients (>70 years) admitted to the ICU.
NAM, well known as a dietary supplement, has also been extensively studied in humans in a variety of diseases in both children and adults. However, the safety, tolerability of NAM in children with JIA is yet unknown. Furthermore, studies performed…
To induce a vaccine specific immune response, hereby we hope to introduce the possibility of a new treatment to improve patient outcome and survival.
The ATLAS-A/B trial (ALN-AT3SC-004) is a multicenter, multinational, randomized, openlabel Phase 3 study designed to demonstrate the efficacy and safety of fitusiran in patients with hemophilia A or B without inhibitory antibodies to FVIII or FIX…