Search for a trial

Randomized phase II study assessing the combination of Vinflunine with Gemcitabine and Vinflunine with Carboplatin in patients ineligible to cisplatin with advanced or metastatic transitional cell carcinoma of the urothelium

Primary objective:· To determine the disease control rate as defined by RECIST assessment criteria [Complete Response (CR) + Partial Response (PR) + Stable Disease (SD) rates] for both Vinflunine-Gemcitabine and Vinflunine-Carboplatin combinations.…

PTSD as a result of interpersonal violence in the primary support group in childhood: Imaginairy Exposure versus Imaginairy Rescripting versus. Drama Rescripting

The research aims to review and compare imaginairy exposure to new forms of treatment for patients with comorbid PTSD due to multiple and repeated abuse in childhood within the primary support group. It is expected that these new forms of treatment…

Multiple-Dose Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, and
Tolerability of Apixaban in Paediatric Subjects with an Indwelling Central Venous
Catheter

There is no formal primary research hypothesis to be statistically tested. The purpose of this study is to evaluate the pharmacokinetics, the pharmacodynamics, the safety profile and tolerability following multiple oral doses of apixaban in…

Phase II study: Radiofrequency ablation of irresectable locally advanced pancreatic cancer

Primary Objective: The proposed project involves a phase II study to investigate the feasibility and safety of radiofrequency ablation in irresectable locally advanced pancreatic cancer. Secondary Objectives: Secondary objectives of the study are…

A randomized controlled study on the effects of time-limited cognitive behavioural therapy (CBT) for panic disorder with/without agoraphobia and social anxiety disorder with comorbidity.

Primairy goal of the study is to treat anxiety disorder patients more cost-effectively (shorter treatments with equal treatment results).

Ibritumomab followed by a reduced intensity, partial T cell-depleted allogeneic stem cell transplantation and immunomodulation with lenalidomide and DLI in patients with relapsed diffuse large B-cell Non-Hodgkins lymphoma

2.1 Primary objective * To determine the feasibility (as measured by non-relapse mortality after 7 months) of the regimen of Ibritumomab, followed by a reduced intensity, partial T cell-depleted allogeneic stem cell transplantation and…

Renal Denervation in Patients with Uncontrolled Hypertension
SYMPLICITY® Flex

The aim of the study is to evaluate the safety of the Flex catheter and the effect of the renal denervation on blood pressure.

Everolimus (RAD001, Afinitor®) and Cyclophosphamide in Castration and Docetaxel resistant Prostate Cancer, a proof of principle Phase II study.

The primary objective is to study whether treatment with the mTOR inhibitor Everolimus results in an objectable change in phosphorylation of the selected downstream effectors 4eBP1 and p70S6K in human prostate cancer biopsies. A secondary objective…

A randomized, placebo-controlled, double blind, 4-period, cross-over trial, to study the effects of aliskiren, hydrochlorothiazide and moxonidine on endothelial dysfunction in obesity related hypertension

Primary objective: to compare changes in endothelial function in patients with obesity related hypertension after 8 weeks of treatment with aliskiren, moxonidine and HCTZ.Secondary objectives: to compare changes in the following parameters in…

Wear rate of a Highly Cross-Linked polyethylene stabilized with vitamin E in Total Hip Arthroplasty.;A Randomized Controlled Trial

2.1 Primary objectiveTo compare the wear rate 24 months after THA of HXLPE stabilized with vitamin E versus conventional UHMWPE for total joint arthroplasty.2.2 Secondary objectives1. To compare the wear rate at 3,12 and 24 months after THA between…

Joint distraction as a treatment for end stage knee osteoarthritis: a comparison with presently applied surgical alternatives.

1. Is KJD clinically non-inferior to current surgical techniques (HTO and TKP)?2. Is KJD superior to HTO in actual structural repair of cartilage?3. Is KJD cost-effective in the long-term compared to HTO and TKP?

Oocyte vitrification in women at risk of ovarian failure; an observational study with follow-up of children

To determine safety and efficacy of oocyte vitrification.

Prospective feasibility, non-randomized, single arm multicentre, multinational interventional clinical investigation using INSTRUCT therapy for the repair of knee cartilage defects.

This pilot clinical trial has been designed to evaluate the safety and performance of the INSTRUCT scaffold, and to collect preliminary efficacy data

Pilot Study: are human intestinal biopsies usefull as in vitro model for the small intestine

Human intestinal biopsies will be used to further develop an in vitro intestinal model. This model will the be used for future research to study the effect of nutreints and drugs on intestinal function. The human biopsies will be compared with…

Multicenter, double-blind, placebo-controlled, randomized, prospective study of bosentan as adjunctive therapy to inhaled nitric oxide in the management of persistent pulmonary hypertension of the newborn (PPHN)

To assess the efficacy of bosentan in neonates with persistent pulmonary hypertension of the newborn (PPHN) who are in need of continued inhaled nitric oxide (iNO) after at least 4 hours of continuous iNO treatment and to evaluate the…

Improving preconceptional glycaemic regulation using RealTime Continuous Glucose Monitoring in women with type 1 diabetes who have *acceptable but not optimal* HbA1c values: an observational study

This study is designed to investigate whether it is possible to achieve substantial improvement in HbA1c values using RT-CGMS in women with type 1 diabetes with acceptable but not optimal glycaemic control in preconceptional period (which is HbA1c…

"I really want to, but I can't." An effect measurement of 20 neurofeedback treatments on intermediate vocational training students who fall under the theta/beta protocol, as measured by changes in the Bourdon-Wiersma Test, The Outcome Rating Scale, and the tendency of obtained marks.

zie boven

PAclitaxel-eluting balloon in Primary PCI in Amsterdam: 1-year angiographic evaluation of target lesion patency.

The PAPPA-trial was the first prospective clinical study the feasibility and safety of a DEB only strategy in PPCI for STEMI. One-year angiographic follow-up is warranted to evaluate long-term patency of the target lesion. So far there has not been…

A randomized, double-blind, placebo-controlled, serial-cohort, single ascending dose of Xen2174 with bupivacaine interaction study administered intrathecally in healthy volunteers.

The objectives of the study are:To determine the pharmacokinetic and pharmacodynamic interaction of a single ascending dose of Xen2174 with bupivacaine, and in one cohort of Xen2174 alone, when administered intrathecally to healthy volunteers and…

Naltrexone as anti-craving medication in cannabis addicts

The goal of the proposed study is to build knowledge about the effect of Naltrexone in a regular sample of cannabis addicts in a mid-size town. To accomplish this, we propose to: a) do a double blind randomized controlled trial with Naltrexone in…